Department of Epidemiology

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Epidemiology

EPI News

Epigenome-wide association study conducted by Irvin and team

Genetic research regarding blood lipids has largely focused on DNA sequence variation; few studies have explored epigenetic effects. Genome-wide surveys of DNA methylation may uncover epigenetic factors influencing lipid metabolism. To identify whether differential methylation of cytosine-guanine dinucleotides (CpGs) correlated with lipid phenotypes, M. Ryan Irvin, PhD, assistant professor in the Department of Epidemiology, recently isolated DNA from CD4+ T-cells and quantified proportion of sample methylation at over 450,000 CpGs, using the Illumina Infinium HumanMethylation450 Beadchip in 991 participants of the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN).

Johnson and colleagues assess HPV in women in Nepal

Nepal has one of the highest cervical cancer rates in South Asia. Only a few studies in populations from urban areas have investigated type specific distribution of human papillomavirus (HPV) in Nepali women, since data on high-risk HPV (HR-HPV) types are not currently available for rural populations in Nepal. Derek C. Johnson, MPH, graduate assistant in the Department of Epidemiology, aimed to assess the distribution of HR- HPV among rural Nepali women while assessing self-collected and clinician-collected cervico-vaginal specimens as sample collection methods for HPV screening.

Moore and colleagues examine the epidemiology of firework-related injuries among youths

Justin X. Moore, MPH, doctoral candidate in the Department of Epidemiology—along with department colleagues professor and vice chair Gerald McGwin, Jr., PhD, and assistant professor Russell L. Griffin, PhD—recently examined the epidemiology of firework-related injuries among an emergency department (ED) nationally representative population for the years 2000-2010, including whether the type of firework causing the injury is differential by patient demographics and whether the severity of injury is associated with the firework type.

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