Dr. George Howard received his training in biostatistics from the University of North Carolina at Chapel Hill. He has had extensive experience in biostatistics, data management, and the direction of coordinating centers of multicenter studies. He is currently the PI of the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study, a longitudinal cohort study of 30,239 African American and white participants in 48 states. He is the co-PI of statistical analysis center for the Carotid Revascularization Endarterectomy Stenting Trial (CREST), and the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. He has previously been the PI of the coordinating centers for the Insulin Resistance Athersclerosis Study (IRAS) and the Secondary Prevention of Small Subcortical Stroke (SPS3) studies, He has been a co-investigator in numerous epidemiological studies and clinical trials including Atherosclerosis Risk in Communities (ARIC), the Community Hospital-Based Stroke Program, the Postmenopausal Estrogen/Progestin Interventions (PEPI) study, and the Asymptomatic Carotid Atherosclerosis Study (ACAS). In addition to multicenter trials experience, he has also participated in multicenter ultrasound efforts and analyses including ARIC and ACAS. He has published extensively in the analysis of cardiovascular and cerebrovascular risk factors, and has an interest in the development and application of statistical techniques in large multicenter clinical trials and epidemiological studies.