A Multi-Center, Single-Blind, Randomized Study Comparing Thymectomy to No Thymectomy in Non-Thymomatous Myasthenia Gravis (MG) Patients Receiving Prednisone

Study Design: Multi-Centered, Single-Blind, Randomized, Two Arm Trial

Study Objectives: Myasthenia gravis (MG) is an autoimmune disease in which 85% of patients have antibodies to muscle acetylcholine receptors (AchR-Ab) that interfere with neuromuscular transmission. MG frequently causes severe disability that can be lifethreatening. Thymectomy has been established therapy in non-thymomatous MG since 1940, based on retrospective, non-randomized studies. Corticosteroids are now being used increasingly either as the sole treatment or in conjunction with thymectomy. Both therapies have associated adverse effects, and indications for their use based on randomized trial data are lacking.

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