5TH SHORT COURSE ON NEXT-GENERATION SEQUENCING: TECHNOLOGY AND STATISTICAL METHODS

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Held On: Mon 12/14/15 – Thurs 12/17/15
Location: University of Alabama at Birmingham
School of Public Health Building, Room 107
1665 University Blvd
Lodging: Doubletree Hotel by Hilton
808 South 20th Street
Birmingham, AL 35205
(205) 933-9000; fax: (205) 933-0920

SpringHill Suites by Marriott
2024 4th Avenue South
Birmingham, AL 35233
(205) 322-8600; fax: (205) 322-9915

Residence Inn by Marriott-UAB
821 20th Street South
Birmingham, AL 35205
(205) 731-9595; fax: (205) 731-9596

 

  • Overview
  • Faculty
  • Contact

Next-generation sequencing technology is impacting almost all aspects of biomedical research. This technology generates an unprecedented wealth of data that demands novel analysis strategies. While IT infrastructure and bioinformatics developments are obviously required to enable sound information extraction, sophisticated statistical methodologies and algorithms are also essential for interpreting the data. In this regard, we are organizing a NHGRI funded four-day short course, calling statisticians, genetic epidemiologists, bioinformaticians, and genome biologists, to discuss the statistical challenges and opportunities in next-generation sequencing data analysis. We believe that this course will provide a venue for exchanging of cutting-edge information and ideas, and fostering collaborations among methodologists, analysts, and biomedical investigators.

Schedule of Events: Tentative Agenda and Speakers [PDF file]

Mon 12/14/15 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
08:00 - 09:15 AM Registration-Room 121 - Coffee, Tea, Juice, Associate Muffins, Fruit Wanda C. Skipwith/Mary Ann Rice  
09:15- 09:30 AM Introductory Remarks Hemant Tiwari, PhD – UAB  
09:30 - 10:30 AM High Performance DNA Sequencing Shawn Levy, PhD – HudsonAlpha Institute of Biotechnology Video
10:30 - 10:45 AM Discussion Shawn Levy, PhD  
10:45 - 11:00 AM BREAK
11:00 - 12:00 PM Next Generation Sequencing in Methylation Studies Devin Absher, PhD - HudsonAlpha Video
12:00 - 12:15 PM Discussion Devin Absher, PhD  
12:15 - 01:30 PM LUNCH – You are free to try any of the local eating places in the area
01:30 - 02:30 PM From Reads to Genotypes Variant Calling and Assembly Degui Zhi, PhD - UAB Video
02:30 - 02:45PM Discussion Degui Zhi, PhD  
02:45 - 03:00PM BREAK
03:00 - 04:00 PM StatGenLab, a Virtual Machine for Genetic Data Analysis Jelai Wang – Wang Scientific Software Solutions, LLC  
04:00- 05:00 PM Software Demonstration & Hands-on Computing (R & Bioinformatics File Formats) Xiangqin Cui, PhD – UAB  

Tue 12/15/15 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
  Room 121 - Coffee, Tea, Juice, Associated Muffins, Fruit    
09:30 - 10:30 AM Functional Genomics Dan Savic, PhD –
HudsonAlpha
Video
10:30 - 10:45 AM Discussion Dan Savic, PhD  
10:45 - 11:00 AM BREAK
11:00 - 12:00 PM Predicting Causal Variation Greg Cooper, PhD - HudsonAlpha Video
12:00 - 12:15 AM Discussion Greg Cooper, PhD  
12:15 - 01:30 PM LUNCH – You are free to try any of the local eating places in the area
01:30- 02:30 PM Rare Variants Analysis Michael Wu, PhD - Fred Hutchinson Cancer Research Center Video
02:30- 02:45 PM Discussion Michael Wu, PhD  
02:45 - 03:00 PM BREAK
03:00- 06:00 PM Software Demonstration & Hands-on Computing (Exome & Whole Genome NGS) Michael Wu, PhD;
Degui Zhi, PhD
 
07:00- 09:00 PM Dinner/Social @ The Edge of Chaos – 4th Floor, Lister Hill Library Participants & Faculty  

Wed 12/16/15 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
  Room 121 - Coffee, Tea, Juice, Associated Muffins, Fruit    
09:30 - 10:30 AM Transcriptome Analysis Using NGS Xiangqin Cui, PhD - UAB Video
10:30 - 10:45 AM Discussion Xiangqin Cui, PhD  
10:45 - 11:00 AM BREAK
11:00 - 12:00 PM Analysis of Whole-genome Bisulfite Sequencing Data Karen Conneely, PhD – Emory University Video
12:00 - 12:15AM Discussion Karen Conneely, PhD  
12:15 - 01:30 PM LUNCH BREAK
01:30 - 02:30 PM Introduction to ChIP-Seq Data Analyses Hao Wu, PhD – Emory University Video
02:30 - 02:45 PM Discussion Hao Wu, PhD  
02:45 - 03:00 PM BREAK
03:00- 06:00 PM Software Demonstration & Hands-on Computing (ChiP-seq Software, BSmooth and DSS) Hao Wu, PhD; Karen Conneely, PhD  

Thu 12/17/15 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
  Room 121 - Coffee, Tea, Juice, Associated Muffins, Fruit    
09:30 - 10:30 AM Cloud Computing Jonas Almeida, PhD – Stony Brook University Video
10:30 - 10:45 AM Discussion Jonas Almeida, PhD  
10:45 - 11:00 AM BREAK
11:00 - 12:00 PM Galaxy David Crossman, PhD, UAB Video
12:00 - 12:15 PM Discussion David Crossman, PhD  
12:15- 01:30 PM LUNCH – You are free to try any of the local eating places in the area
01:30 - 02:45 PM Hands-on with Galaxy David Crossman, PhD  
02:45 - 03:00 PM BREAK
03:00 - 05:00 PM Software Demonstration & Hands-on Computing (RNA-Seq) Xiangqin Cui, PhD  
05:00 PM Adjourn

 

UAB Faculty:

External Faculty:

Full List of Rotating Faculty can be found by Click here.

Contact Information:

Logistics: Wanda C. Skipwith
Department of Biostatistics
1665 University Blvd, RPHB 414
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 975-9193
Email: Statgenetics@uab.edu

Scientific: Hemant K Tiwari, PhD
Department of Biostatistics
1665 University Blvd, 420C
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 934-4907
Email: htiwari@uab.edu

 

Sponsors:  National Human Genome Research Institute
Section on Statistical Genetics, University of Alabama at Birmingham
HudsonAlpha


NHGRI Disclaimer: This material is based upon work supported by the National Human Genome Research Institute (NHGRI) under Grant No. R25HG006110. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NHGRI.