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2ND SHORT COURSE ON NEXT-GENERATION SEQUENCING: TECHNOLOGY AND STATISTICAL METHODS

Details and Registration Information:  pdf   MS Word
Held On: Mon 12/10/12 – Thurs 12/13/12
Lodging: Doubletree Hotel Birmingham
808 South 20th Street
Birmingham, AL 35205
(205) 933-9000; fax (205) 933-0920
*mention that you are coming at the request of UAB for our short course for the rate ($114/night; gov't rate not offered)
Location: Meeting Room on the ground floor of the:
Doubletree Hotel Birmingham
808 South 20th Street
Birmingham, AL 35205
View more information.

 

  • Overview & Agenda
  • Faculty
  • Contact

Next-generation sequencing technology is impacting almost all aspects of biomedical research. This technology generates an unprecedented wealth of data that demands novel analysis strategies. While IT infrastructure and bioinformatics developments are obviously required to enable sound information extraction, sophisticated statistical methodologies and algorithms are also essential for interpreting the data. In this regard, we are organizing a NHGRI funded four-day short course, calling statisticians, genetic epidemiologists, bioinformaticians, and genome biologists, to discuss the statistical challenges and opportunities in next-generation sequencing data analysis. We believe that this course will provide a venue for exchanging of cutting-edge information and ideas, and fostering collaborations among methodologists, analysts, and biomedical investigators.

Schedule of Events: [PDF file]

Mon 12/10/12 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
08:30 - 09:15 AM Registration Derry Crawford  
09:15 - 09:30 AM Introductory Remarks Hemant Tiwari,  PhD  
09:30 - 10:45 AM Overview of Genetics & Genomics (Intro: Sequencing for Variation & Functional Genomics) Greg Barsh, PhD Video
10:45 - 11:00 AM BREAK
11:00 - 12:15 PM Technical overview of NGS (Platforms; chemistry; library construction) Shawn Levy, PhD Video
12:15 - 1:30 PM Lunch
01:30 - 02:45 PM Primary Data Analysis (Base calling; alignment; QC; variant calling) Shawn Levy, PhD Video
02:45 - 03:00 PM BREAK
03:00 - 04:15 PM Copy Number & Structural Variants (biology; experimental methods; analysis) Devin Absher, PhD Video
04:15 - 04:30PM BREAK
04:30- 05:00 PM Discussion (Q & A) All Faculty  

Tue 12/11/12 - HudsonAlpha Institute for Biotechnology in Huntsville, AL
Time Topic Speaker Resource(s)
07:30 - 07:45 AM Gather in Hotel Lobby for departure
07:45 - 9:15 AM Bus Transportation to HudsonAlpha in Huntsville
09:15 - 9:30AM Gather in HudsonAlpha meeting room
09:30 - 10:00 AM Computing Needs for NGS (Computing & storage needs; data handling) Braden Boone, MS, MIT Video
10:00 - 11:00 AM DNA Sequence Variant Annotation and Analysis Greg Cooper, PhD Video
11:00 - 11:15 PM BREAK
11:15 - 12:15 PM RNA-seq (mRNA & microRNA; EDGE RNA-seq, a SAGE-like, Counting Method Developed by Greg Barsh's lab) Jay Gertz, PhD Video
12:15 - 01:30 PM LUNCH
01:30- 02:30 PM Genome-scale DNA methylation analysis Devin Absher, PhD Video
02:30- 03:30 PM ChIP-seq (protein:DNA Interactions on a Genome-wide Scale) Rick Myers, PhD Video
03:30 - 03:45 PM BREAK
03:45 - 05:00 PM Discussion (Q & A) & Tour of sequencing facility All Faculty  
05:00 - 06:30 PM Bus Transportation to Hotel in Birmingham

Wed 12/12/12 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
09:00 - 10:15 AM Analysis of  Whole Genome Transcriptome Sequencing Data Xiangqin Cui, PhD Video
10:15 - 10:30 AM BREAK
10:30 - 11:45AM Analysis of NGS data using Galaxy David Crossman, PhD Video
11:45 - 01:15 PM Lunch
01:15 - 02:30 PM Whole Genome 3D Regulation Analysis Using Sequencing Shili Lin, PhD Video
02:30 - 02:45 PM BREAK
03:00 - 04:15 PM Cloud Computing and Semantic Web application to High-Dimensional Biomedical Data Jonas Almeida, PhD Video
04:15 - 05:00 PM Discussion (Q & A) All Faculty  

Thu 12/13/12 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
09:00 - 10:15 AM Rare Variants Association Analysis Suzanne Leal, PhD Video
10:15 - 10:30 AM BREAK
10:30 - 11:45 AM The 1000 Genomes Project: Behind and Beyond the Creation of Phase 1 Data Yun Li, PhD Video
11:45- 01:15 PM Lunch
01:15 - 02:30 PM Assembling NGS data Degui Zhi, PhD Video
02:30 - 03:00 PM Discussion (Q & A) All Faculty  

 

UAB Faculty:

External Faculty:

Full List of Rotating Faculty can be found by Click here.


Contact Information:

Logistics: Wanda Skipwith or Derry Crawford
Department of Biostatistics
1665 University Blvd, RPHB 414
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 975-9193 or 975-9298
Email: Statgenetics@uab.edu

Scientific: Hemant K Tiwari, PhD
Department of Biostatistics
1665 University Blvd, 420B
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 934-4907
Email: htiwari@uab.edu

 

Sponsors:  National Human Genome Research Institute
Section on Statistical Genetics, University of Alabama at Birmingham
HudsonAlpha


NHGRI Disclaimer:
This material is based upon work supported by the National Human Genome Research Institute (NHGRI) under Grant No. R25HG006110. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NHGRI.

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