7TH SHORT COURSE ON NEXT-GENERATION SEQUENCING: TECHNOLOGY AND STATISTICAL METHODS

Registration: https://www.soph.uab.edu/ssg/nhgri_r25/seventhshortcourse/application
The registration deadline for the course has expired.

Held On:

Mon 12/18/17 – Thu 12/21/17

Location:

University of Alabama at Birmingham
1665 University Blvd, RPHB 107
Birmingham, Al 35294
https://www.uab.edu/map/?ryals

Lodging:

SpringHill Suites Downtown UAB
2024 4th Avenue South
Birmingham, Alabama 35233
205-322-8600 – Office 205-322-9915 – Fax
ROOM RATE: 139.86 (tax included) 2 Queen Beds
Check in Time: 3:00PM – Check Out Time: 12:00PM
Book your group rate for UAB School of Public Health
Cancellation: by 6PM day of scheduled arrival

GROUP ACCOMMODATIONS INCLUDE:

  • Complimentary Breakfast
  • Complimentary Wi-Fi
  • Complimentary Guest Laundry
  • Adjacent Parking Garage @ $10.00 per day

METERED PARKING: Available along the street in front of the hotel- typically free on the weekends.

Doubletree Hotel by Hilton
808 South 20th Street
Birmingham, AL 35205
(205) 933-9000; fax: (205) 933-0920

Residence Inn by Marriott
821 South 20th Street
Birmingham, Al 35205
(205) 521-7392; Fax: (205) 731-9596

  • Overview
  • Faculty
  • Contact

Next-generation sequencing technology is impacting almost all aspects of biomedical research. This technology generates an unprecedented wealth of data that demands novel analysis strategies. While IT infrastructure and bioinformatics developments are obviously required to enable sound information extraction, sophisticated statistical methodologies and algorithms are also essential for interpreting the data. We are calling statisticians, genetic epidemiologists, bioinformaticians, and genome biologists, to discuss the statistical challenges and opportunities in next-generation sequencing data analysis. We believe that this course will provide a venue for exchanging of cutting-edge information and ideas, and fostering collaborations among methodologists, analysts, and biomedical investigators.

Schedule of Events: Agenda

Mon 12/18/17
Time Topic Speaker Resource(s)
08:00 - 09:15 AM Registration Wanda Skipwith  
09:15 - 09:30 AM Introductory Remarks Hemant Tiwari  PhD  
09:30 - 10:30 AM Technical Overview of NGS (Platforms; chemistry; library construction) Shawn Levy PhD Video
10:30 - 10:45 AM Discussion Shawn Levy PhD  
10:45 - 11:00 AM BREAK
11:00 - 12:00 PM Next Generation Sequencing in Methylation Studies Devin Absher, PhD Video
12:00 - 12:15 PM Discussion Devin Absher, PhD  
12:15 - 01:30 PM LUNCH BREAK (Local Restaurants)
01:30 - 02:30 PM Decoding the Regulatory Genome through Functional Genomics and high-throughput assays Dan Savic, PhD Video
02:30 - 02:45PM Discussion Dan Savic, PhD  
02:45 - 03:00PM BREAK
03:00 - 04:00 PM Introduction to Virtual Machine Vinodh, MS  
04:00 - 06:00 PM Software Demonstration & Hands-on Computing (R & Bioinformatics File Formats) Vinodh, MS  

Tue 12/19/17
Time Topic Speaker Resource(s)
09:00 - 10:00 AM Variant Calling & Assembly NGS Data David Crossman, PhD Video
10:00 - 10:15 AM Discussion David Crossman, PhD  
10:15 - 10:30 AM BREAK
10:30 - 11:30 PM Predicting Causal Variation Greg Cooper, PhD Video
11:30 - 11:45 AM Discussion Greg Cooper, PhD  
11:45 - 01:15 PM LUNCH BREAK (Local Restaurants)
01:15 - 02:15 PM Rare Variants Analysis Michael Wu, PhD Video
02:15 - 02:30 PM Discussion Michael Wu, PhD  
02:30 - 02:45 PM BREAK
02:45- 05:00 PM Software Demonstration & Hands-on Computing (Exome & Whole Genome NGS) Michael Wu, PhD, David Crossman, PhD  

Wed 12/20/17
Time Topic Speaker Resource(s)
09:00 - 10:00 AM Structural Variant Analysis Zechen Chong, PhD Video
10:00 - 10:15 AM Discussion Zechen Chong, PhD  
10:15 - 10:30 AM BREAK
10:30 - 11:30 PM Transcriptome Analysis Xiangqin Cui, PhD Video
11:30 - 11:45AM Discussion Xiangqin Cui, PhD  
11:45 - 01:15 PM LUNCH BREAK (Local Restaurants)
01:15 - 02:15 PM Methylation using Bisulfite Sequencing Karen Conneely, PhD Video
02:15 - 02:30PM Discussion Karen Conneely, PhD  
02:30 - 02:45 PM BREAK
02:45- 06:00 PM Software Demonstration & Hands-on Computing (RNA-Seq, BSmooth, DSS) Xiangqin Cui, PhD; Karen Conneely, PhD  

Thu 12/21/17
Time Topic Speaker Resource(s)
09:00 - 10:00 AM ChiP-Seq Data Analysis Hao Wu, PhD Video
10:00 - 10:15 AM Discussion Hao Wu, PhD  
10:15 - 10:30 AM BREAK
10:30- 11:30 PM Single Cell RNA-Seq Analysis Hao Wu, PhD Video
11:30 - 11:45 PM Discussion Hao Wu, PhD  
11:45- 01:15 PM LUNCH BREAK (Local Restaurants)
01:15- 03:00 PM Software Demonstration & Hands-on Computing (ChipSeq) Hao Wu, PhD  
03:00 PM Adjourn

 

UAB Faculty:

External Faculty:

Full List of Rotating Faculty can be found by Click here.

Contact Information:

Logistics: Wanda C. Skipwith
Department of Biostatistics
1665 University Blvd, RPHB 414
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 975-9193
Email: Statgenetics@uab.edu

Scientific: Hemant K Tiwari, PhD
Department of Biostatistics
1665 University Blvd, 420C
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 934-4907
Email: htiwari@uab.edu

 

Sponsors: National Human Genome Research Institute
UAB Department of Biostatistics
HudsonAlpha


NHGRI Disclaimer: This material is based upon work supported by the National Human Genome Research Institute (NHGRI) under Grant No. R25HG006110. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NHGRI.