6TH SHORT COURSE ON NEXT-GENERATION SEQUENCING: TECHNOLOGY AND STATISTICAL METHODS

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Registration: Closed

Held On:

Mon 12/12/16 – Thu 12/15/16

Location:

University of Alabama at Birmingham
Learning Resource Center, Room 210
1714 9th Avenue South
Birmingham, Al 35294
http://www.uab.edu/map/?learning-resource-center

Lodging:

Doubletree Hotel by Hilton
808 South 20th Street
Birmingham, AL 35205
(205) 933-9000; fax: (205) 933-0920

The Hotel Highland
1023 South 20th Street
Birmingham, AL 35205
(205) 966-9555; Fax:  (205) 933-6918

Residence Inn by Marriott
821 South 20th Street
Birmingham, Al 35205
(205) 521-7392; Fax: (205) 731-9596

 

  • Overview
  • Faculty
  • Contact

Next-generation sequencing technology is impacting almost all aspects of biomedical research. This technology generates an unprecedented wealth of data that demands novel analysis strategies. While IT infrastructure and bioinformatics developments are obviously required to enable sound information extraction, sophisticated statistical methodologies and algorithms are also essential for interpreting the data. In this regard, we are organizing a NHGRI funded four-day short course, calling statisticians, genetic epidemiologists, bioinformaticians, and genome biologists, to discuss the statistical challenges and opportunities in next-generation sequencing data analysis. We believe that this course will provide a venue for exchanging of cutting-edge information and ideas, and fostering collaborations among methodologists, analysts, and biomedical investigators.

Schedule of Events: Tentative Agenda and Speakers

Mon 12/12/16 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
08:00 - 09:15 AM Registration- Continental Breakfast Wanda Skipwith/Mary Ann Rice  
09:15- 09:30 AM Introductory Remarks Hemant Tiwari  PhD  
09:30 - 10:30 AM Technical Overview of NGS (Platforms; chemistry; library construction) Shawn Levy PhD Video
10:30 - 10:45 AM Discussion Shawn Levy PhD  
10:45 - 11:00 AM BREAK
11:00 - 12:00 PM Next Generation Sequencing in Methylation Studies Devin Absher, PhD Video
12:00 - 12:15 PM Discussion Devin Absher, PhD  
12:15 - 01:30 PM Lunch Break
01:30 - 02:30 PM Variant Calling & Assembly NGS Data David Crossman, PhD Video
02:30 - 02:45PM Discussion David Crossman, PhD  
02:45 - 03:00PM BREAK
03:00 - 04:00 PM Introduction to Virtual Machine Jelai Wang  
04:00- 05:00 PM Software Demonstration & Hands-on Computing (R & Bioinformatics File Formats) Xiangqin Cui, PhD  

Tue 12/13/16 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
  Continental Breakfast    
09:00 - 10:00 AM Decoding the regulatory genome through functional genomics and high-throughput assays Dan Savic, PhD Video
10:00 - 10:15 AM Discussion Dan Savic, PhD  
10:15 - 10:30 AM BREAK
10:30 - 11:30 PM Predicting Causal Variation Greg Cooper PhD Video
11:30 - 11:45 AM Discussion Greg Cooper PhD  
11:45 - 01:15 PM Lunch Break
01:15- 02:15 PM Rare Variants Analysis Michael Wu, PhD Video
02:15- 02:30 PM Discussion Michael Wu, PhD  
02:30 - 02:45 PM BREAK
02:45- 05:00 PM Software Demonstration & Hands-on Computing (Exome & Whole Genome NGS) Michael Wu, PhD, David Crossman, PhD  
06:00- 08:00 PM Social Dinner @ Hill Student Center (Ball Room B) 1400 University Blvd. Participants & Faculty  

Wed 12/14/16 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
09:00 - 10:00 AM Microbiome/ Metagenome Nengjun Yi, PhD Video
10:00 - 10:15 AM Discussion Nengjun Yi, PhD  
10:15 - 10:30 AM BREAK
10:30 - 11:30 PM ChiP-Seq Data Analysis Hao Wu, PhD Video
11:30 - 11:45AM Discussion Hao Wu, PhD  
11:45 - 01:15 PM LUNCH BREAK
01:15 - 02:15 PM Methylation using Bisulfite Sequencing Karen Conneely, PhD Video
02:15 - 02:30PM Discussion Karen Conneely, PhD  
02:30 - 02:45 PM BREAK
02:45- 06:00 PM Software Demonstration & Hands-on Computing (ChipSeq) & Methylation Data Hao Wu, PhD; Karen Conneely, PhD  

Thu 12/15/16 - UAB in Birmingham, AL
Time Topic Speaker Resource(s)
09:00 - 10:00 AM RNA-Seq Analysis Methods Xiangqin Cui, PhD Video
10:00 - 10:15 AM Discussion Xiangqin Cui, PhD  
10:15 - 10:30 AM BREAK
10:30- 11:30 PM Single Cell Sequencing Hao Wu, PhD Video
11:30 - 11:45 PM Discussion Hao Wu, PhD  
11:45- 01:15 PM Lunch Break
01:15- 02:15 PM Software Demonstration of Analysis of Microbiome data Ranjit Kumar, PhD  
02:15 - 02:30 PM BREAK
02:30 - 05:00 PM Software Demonstration RNA-Seq
Software Demonstration single cell RNA-Seq
Xiangqin Cui, PhD
Hao Wu, PhD
 
05:00 PM Adjourn

 

UAB Faculty:

External Faculty:

Full List of Rotating Faculty can be found by Click here.

Contact Information:

Logistics: Wanda C. Skipwith
Department of Biostatistics
1665 University Blvd, RPHB 414
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 975-9193
Email: Statgenetics@uab.edu

Scientific: Hemant K Tiwari, PhD
Department of Biostatistics
1665 University Blvd, 420C
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 934-4907
Email: htiwari@uab.edu

 

Sponsors:  National Human Genome Research Institute
UAB Department of Biostatistics
HudsonAlpha


NHGRI Disclaimer: This material is based upon work supported by the National Human Genome Research Institute (NHGRI) under Grant No. R25HG006110. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NHGRI.