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4th Short Course on Statistical Genetics and Genomics

Details and Registration Information:  Word    PDF

When: Monday 7/7/14 – Friday 7/11/14
Location: University of Alabama at Birmingham
1401 University Blvd.
1st Floor Heritage Hall – Lecture Room 104
Birmingham, AL 35233
http://www.uab.edu/map/hhb
Lodging Options: Doubletree Hotel by Hilton
808 South 20th Street
Birmingham, AL 35205
(205) 933-9000; fax: (205) 933-0920


SpringHill Suites by Marriott

2024 4th Avenue South
Birmingham, AL 35233
(205) 322-8600; fax: (205) 322-9915

Residence Inn by Marriott-UAB
821 20th Street South
Birmingham, AL 35205
(205) 731-9595; fax: (205) 731-9596

  • Overview & Agenda
  • Bursary Award
  • Travel Award
  • Faculty & Board
  • Apply
  • Contact

Overview

Major efforts are under way to uncover the specific genetic components of many complex human disorders and quantitative traits. These efforts are generating an unprecedented wealth of data that requires sophisticated statistical analysis in order to maximize the information gleaned from each study. Likewise, many advances have been made in statistical methods for the study of complex genetic traits, and new statistical methods continue to be promulgated. To expedite and significantly advance the search for specific genes that predispose to these complex traits, we propose a series of annual hands-on short courses on statistical genetics and statistical genomics which will enable a far greater number of researchers, including clinical researchers, to participate in, contribute to, and lead such research. These short courses will help equip students, post-doctoral fellows, programmers who are working with funded investigators, junior investigators, and senior investigators new to the field with the statistical genetic approaches necessary to expedite genomic discovery. The courses will be taught by leading experts in statistical genetics/genomics. Each 5-day course will provide substantial "hands-on" computer training that will effectively increase the number and the expertise of investigators who are pursuing genetic and genomic research. We expect approximately 50 students to attend each course, allowing for intensive interaction between students and faculty. Lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. Finally, we will also initiate a new bursary service, providing funding for 10 course participants to travel to visit a course faculty member of their choice to help initiate or finish a particular project. This will provide an unprecedented collaborative opportunity for course participants and faculty.

Schedule of Events: Agenda

Monday 7/7/14
Time Speaker Topic Resource(s)
08:00 - 08:30 Derry Crawford Registration  
08:30 - 08:45 Hemant Tiwari, PhD Introductory Remarks  
08:45 - 09:45 Ellen Clayton, MD/JD Ethical Issues in Medical Research in Human Genetics  
09:45 - 10:00   BREAK
10:00 - 11:00 Ellen Clayton, MD/JD Part II - Ethical Issues in Research in Human Genetics  
11:00 - 11:15   BREAK
11:15 - 12:15 Nancy Cox, PhD Statistical Genetics & Genomics  
12:15 - 01:30   LUNCH BREAK
01:30 - 03:00 Sanjay Shete, PhD Introduction to Biostatistics  
03:00 - 03:15   BREAK
03:15 - 04:15 Jelai Wang StatGenLab, a virtual machine for genetics data analysis  
04:15 - 06:00 Xiangqin Cui PhD Introduction to R & Bio-conductor  

 

Tuesday 7/8/14
Time Speaker Topic Resource(s)
08:00 - 09:15 Hemant Tiwari, PhD Design, Analysis, and interpretation of GWAS – GWAS (I)  
09:15 - 09:30   BREAK
09:30 - 10:45 Hemant Tiwari, PhD X-Chromosome, Imputation to 1000 Genomes - GWAS (II)  
10:45 - 11:00   BREAK
11:00 - 12:15 Michael Wu, PhD Rare Variants Analyses  
12:15 - 01:30   LUNCH BREAK  
01:30 - 02:00 Faculty Open Discussion
02:00 - 02:15   BREAK
02:15 - 06:00 Wang and Wu PLINK, SKAT  
07:00 - 09:00 Participants & Faculty Social and Dinner  

 

Wednesday 7/9/14
Time Speaker Topic Resource(s)
08:00 - 09:15 Rui Feng, PhD Structural Variation & Human Diseases (CNV Analysis)  
09:15 - 09:30   BREAK
09:30 - 10:45 Marylyn Ritchie, PhD Gene x Gene & Gene x Environment Interaction  
10:45 - 11:00   BREAK
11:00 - 12:15 Alison Motsinger-Reif, PhD Pharmacogenetics/ Pharmacogenomics  
12:15 - 01:30   LUNCH BREAK  
01:30 - 02:00 Faculty Open Discussion
02:00 - 02:15   BREAK
02:15 - 06:00 Rui Feng & Srinivasa PENNCNV, Imputation using MACH  

 

Thursday 7/10/14
Time Speaker Topic Resource(s)
08:00 - 09:15 Xiangqin Cui, PhD Transcriptome analyses  
09:15 - 09:30   BREAK
09:30 - 10:45 Hao Wu, PhD Statistical Epigenomics  
10:45 - 11:00   BREAK
11:00 - 12:15 Karen Conneely, PhD Analysis of DNA Methylation Microarray Data  
12:15 - 01:30   LUNCH BREAK
01:30 - 02:45 Faculty Open Discussion
02:45 - 03:00   BREAK
03:00 - 06:00 Conneely and Wu CpGassoc, NGS analysis with Bioconductor  

 

Friday 7/11/14
Time Speaker Topic Resource(s)
08:00 - 09:15 Nicholas J Schork, PhD Statistical Methods for NGS  
09:15 - 09:30   BREAK
09:30 - 10:45 Purvesh Khatri, PhD Beyond GWAS: Pathway Analysis and Meta-Analysis  
10:45 - 12:00 All Faculty Open Discussion  
12:00 - 01:30   LUNCH BREAK
1:30 - 2:30      
02:30   Adjourn

 

NIGMS Bursary Award

We will offer a novel service to participants to assist them either in their ongoing research projects or in a newly initiated project which could lead to publication in a refereed journal, or submission of an investigator initiated grant proposal.  In addition to attending the regularly scheduled short course itself, one month after the short course participants will be encouraged to submit a one page proposal on their projects, indicating in each case the specific aim of the project and the name of the rotating faculty with whom they wish to work.  The submitted proposal must include information detailing how much work has been done, and also, what work needs to be done.  Any faculty listed in the rotating faculty list is eligible to provide such service; it is the responsibility of the participant to initially contact the rotating faculty member and request assistance with their project.  Even so, we can serve as facilitators; contacting particular faculty to ask whether they are willing to help the participant in initiating and finishing the project.  If they agree, we will encourage the award recipients to contact the faculty to arrange to work on the project.  Advisory board members will serve as reviewers and will assign scores between 1 and 5 to each proposal, and convey them to Dr. Tiwari.  We will then select the 10 participants with highest average scores.  (In selecting the proposals for Bursary Awards, we also consider diversity in addition, but secondarily, to the scientific quality of the proposal).  When the project is nearly complete, the participant will visit the faculty for at least two days to get final assistance.

Within one month of the Bursary Service end date, both participant and faculty will be responsible to provide feedback on their experience and to provide information on the manuscript or grant proposal that they submitted together.  They may be asked to provide a copy of their manuscript and/or confirmation of the submitted grant proposal (the documents will not be distributed to anyone and will be kept confidential).  We will also keep track of publication status as well as the approval of the grant proposal by conducting online searches of Pub Med, Medline, and NIH RePORTER to find out whether any of these trainees have publications or funded grants, especially in fields related to genetics.  We strongly believe that this will bring high level of collaboration between faculty and participants.

NIGMS Travel Fellowship Award

We offer a Travel Fellowship Award to applicants to assist them with the funding of their travel to UAB to participate in the Short Course. If you are awarded a travel fellowship, your travel, hotel, & food costs will be covered up to an amount of $2050.00; your registration fee will not be waived. Those awarded the travel fellowship should request and save all of their original itemized receipts pertaining to their food, travel, & hotel expenses, and submit them to us after the short course is over. Once approved, we will issue a reimbursement of those expenses up to $2050.00. NOTE: non-itemized receipts will not be reimbursed.

In order to be considered for the Travel Fellowship Award, applicants must submit a brief proposal on their research project(s), indicating in each case the specific aim of the project. The submitted proposal must include information detailing how much work has been done, and also, what work needs to be done. Background information describing the applicant’s experiences in statistics, genetics, programming, etc. should also be included in the proposal.

Applicants must also submit at a minimum, two letters of recommendation in order to be considered for the award.

The travel fellowships are available for graduate students, post-doctoral fellows, and early investigators who are US Citizens/Permanent Residents or who are currently studying and/or working at a US Institution.

UAB Faculty:

Full List of Rotating Faculty can be found by Click here.

Advisory Board:

  • Robert C Elston, PhD - Statistical Genetics/Genomics, Case Western Reserve University, Cleveland, Ohio
  • Suzanne M Leal, PhD - Linkage/ Association, Department of Molecular and Human Genetics, Baylor University, Houston
  • John K Hewitt, PhD - Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado

Apply

Application deadline:
Applications for 2014 NIGMS Short Course on Statistical Genetics & Genomics will be accepted till Friday May 30, 2014.

How to Apply
To apply, please perform the following tasks either via our website or by sending materials to derry@uab.edu:

  1. Complete this application form (PDF or Word).   Only fully completed application forms will be considered.
  2. Forward your current curriculum vitae.
  3. (required for Travel Fellowship Award and/or Bursary Award consideration) One page proposal on a research project including the specific aim of the project. [Bursary Award - we will offer a novel service to selected participants to assist them either in their ongoing research projects or in a newly initiated project which could lead to publication in a refereed journal, or submission of an investigator initiated grant proposal]. Questions?  Contact Dr. Hemant Tiwari – htiwari@uab.edu
  4. (required only for Travel Fellowship Award consideration)  Letters of recommendation (minimum of two).

Attendance is limited. Please apply prior to Fri 5/30/2014. Accepted applicants will be notified by Mon 6/2/2014, and applicants should make arrangements for payment of the registration fee by June 21st.

Women, members of underrepresented minority groups, and individuals with disabilities are strongly encouraged to apply.

Upon Acceptance, fee: 
          $600 - academic, government, and non-profit organizations
          $2,600 - for-profit organizations

Acceptance includes course tuition, syllabus, and refreshment breaks.  Fee will be payable upon acceptance into the course.

Email your application, CV/resumes, research proposals, and letters of recommendation to: derry@uab.edu

For more information, contact:
Derry Crawford, MSHA
Program Manager
UAB SOPH Department of Biostatistics
Section on Statistical Genetics
1665 Univ. Blvd, RPHB 414
Birmingham, AL 35294-0022
205.975.9298 T
205.975.2541 F
derry@uab.edu


Contact Information:

Logistics: Derry Crawford
Phone: (205) 975-9298
Email: statgenetics@uab.edu

 

Scientific: Hemant K Tiwari, PhD
Department of Biostatistics
1665 University Blvd, 420B
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 934-4907
Email: htiwari@uab.edu


Funding Sources:

National Institute of General Medical Sciences (NIGMS)

SSG

NIGMS Disclaimer:
This material is based upon work supported by the National Institute of General Medical Sciences (NIGMS) under Grant No. R25GM093044. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NIGMS.

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