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Yann C. Klimentidis PhD

Richard Kennedy, M.D., Ph.D. Department of Biostatistics
Ryals Public Health Bldg, 424A
University of Alabama at Birmingham
Birmingham, AL 35294
Phone: (205) 975-9273
Fax: (205) 975-2540
E-mail: yann@ms.soph.uab.edu
Full CV
Current Webpage at the Office of Energetics


I received my undergraduate degree in Biology at Texas A&M University and my PhD in Anthropology from the University of New Mexico. My dissertation research involved the use of genetic admixture to examine social, phenotypic, and obesity-related characteristics of Hispanics and Native Americans in New Mexico.

I joined the Section on Statistical Genetics in January of 2009. I will be working with Drs. David Allison and Jose Fernandez on the genetics of obesity and cardiovascular disease, specifically using genetic admixture to examine health disparities, as well as developing methods to use genomic-scale data to examine signals of evolutionary change.

Publications
 

  • 2011
  • 2010
  • 2009
  • 2003
  • 2001
  1. Paulina Gomez-Rubio, Yann C. Klimentidis, Ernesto Cantu-Soto, Maria M. Meza-Montenegro, Dean Billheimer, Zhenqiang Lu, Zhao Chen, Walter Klimecki. Indigenous American ancestry is associated with arsenic methylation efficiency in an admixed population of northwest Mexico. Journal of Toxicology and Environmental Health. In press.
     
  2. Yann C. Klimentidis, Brahim Aissani, Mark Shriver, David B. Allison, Sadeep Shrestha (2011). Natural Selection among Eurasians at genomic regions associated with HIV-1 control. BMC Evolutionary Biology. 11: 173. [PMID: 21689440]
     
  3. Yann C. Klimentidis, Guo-Bo Chen, Mardya Lopez-Alarcon, Jacqueline Harris, Christine Duarte, Jose Fernandez (2011). Testing the association of GWAS-identified variants with obesity-related traits in a multi-ethnic sample of children. Archives of Medical Research. In press.
     
  4. Robert Makowsky, Nicholas Pajewski, Yann C. Klimentidis, Ana I. Vasquez, Christine Duarte, David B. Allison, Gustavo de los Campos (2011) Beyond missing heritability: Prediction of complex traits. PLoS Genetics 7(4): e1002051. [PMID: 21552331]
     
  5. Yann C. Klimentidis, Marshall Abrams, Jelai Wang, Jose R. Fernandez, David B. Allison (2011) Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions. Human Genetics. 129: 407-418. [PMID: 21188420]
     
  6. Klimentidis YC, Dulin-Keita A, Casazza K, Willig AL, Allison DB, Fernandez JR. (2011) Genetic admixture, social-behavioural factors and body composition are associated with blood pressure differently by racial-ethnic group among children. J Hum Hypertens. 2011 Jan 20. [Epub ahead of print] [PMID: 21248781]
     
  7. Yann C. Klimentidis, T. Mark Beasley, Hui-Yi Lin, Giulianna Murati, Gregory E. Glass, Marcus Guyton, Wendy Newton, Matthew Jorgensen, Steven B. Heymsfield, Joseph Kemnitz, Lynn Fairbanks, & David B. Allison (2011) Canaries in the Coal Mine: A Cross-Species Analysis of the Plurality of Obesity Epidemics. Proceedings of the Royal Society, B. 278(1712):1626-32 [PMID: 21106594]
     
  8. Yann C. Klimentidis, Jasmin Divers, Krista Casazza, David B. Allison, Jose R. Fernandez (2011) Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children. Human Genomics, Jan;5(2):79-89. [PMID: 21296741]
     
  1. Maria De Luca, Yann C. Klimentidis, Krista Casazza, Michelle Moses Chambers, Ruth Cho, Susan T. Harbison, Patricia Jumbo-Lucioni, Shaoyan Zhang, Jeff Leips, and Jose R. Fernandez. (2010) A conserved role for syndecan family members in the regulation of whole-body energy metabolism. PLoS One 5(6): e11286 [PMID: 20585652]
     
  2. Thomas C. Friedrich, Shari M. Piaskowski, Enrique J. Léon, Jessica R. Furlott, Nicholas J. Maness, Kimberly L. Weisgrau, Caitlin E. Mac Nair, Andrea M. Weiler, John T. Loffredo, Matthew R. Reynolds, K Y. Williams, Yann C. Klimentidis, Nancy A. Wilson, David B. Allison, and Eva G. Rakasz. (2010) High viremia is associated with high levels of in vivo MHC-I downregulation in rhesus macaques infected with SIVmac239. Journal of Virology, 84(10):5443-7. [PMID: 20219903]
     
  3. Mauricio A Martins, Nancy A Wilson, Jason S Reed, Chanook D Ahn, Yann C. Klimentidis, David B Allison, and David I Watkins (2010) T-cell correlates of vaccine efficacy after a heterologous SIV challenge. Journal of Virology, 84(9):4352-65. [PMID: 20164222]
  1. Klimentidis Y, Miller G, Shriver MD (2009) The relationship between European genetic admixture and body composition among Hispanics and Native Americans. American Journal of Human Biology. [PMID: 19214998]
     
  2. Klimentidis Y, Shriver MD (2009) Estimating admixture proportions from faces. PLoS One. 4(2):e4460. [PMID: 19223962]
     
  3. Klimentidis Y, Miller G, Shriver MD (2009) Genetic admixture, self-reported ethnicity, self-estimated admixture, and skin pigmentation among Hispanics and Native Americans. American Journal of Physical Anthropology. 24;138(4):375-383. [PMID: 18951390]
     
  4. Laura E. Valentine, John T. Loffredo, Alex T. Bean, Enrique J. León, Caitlin E. MacNair, Dominic R. Beal, Shari M. Piaskowski, Yann C. Klimentidis, Simon M. Lank, Roger W. Wiseman, Jason T. Weinfurter, Gemma E. May, Eva G. Rakasz, Nancy A. Wilson, Thomas C. Friedrich, David H. O'Connor, David B. Allison, and David I. Watkins (2009) Infection with "escaped" virus variants impairs control of SIVmac239 replication in Mamu-B*08+ macaques. Journal of Virology, 83(22) 11514-27. [PMID: 19726517]
  1. Hadsell DL, Bonnette S, George J, Torres D, Klimentidis Y, Gao S, Haney PM, Summy-Long J, Soloff MS, Parlow AF, Sirito M, Sawadogo M (2003) Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G. Molecular Endocrinology 17(11):2251-67. [PMID: 12907752]
     
  1. Hadsell DL, Alexeenko T, Klimentidis Y, Torres D, Lee AV (2001) Inability of overexpressed des(1-3) human insulin-like growth factor I (IGF-I) to inhibit forced mammary gland involution is associated with decreased expression of IGF signaling molecules. Endocrinology 142: 1479-88. [PMID: 11250928]
     

 

Acknowledgement and Disclaimer
The trainee's projects are supported by Grant Number T32HL105346 from the Lung Biology and Translational Medicine. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute Institute or the National Institutes of Health.

Years: 2009 - 2012
Mentor(s): David B. Allison, Ph.D. & José Fernández, Ph.D.
Current Position: Instructor, School Of Public Health Dean's Office, The University of Alabama at Birmingham