Hemant Tiwari, Ph.D.

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Hemant Tiwari, Ph.D. Professor
Department of Biostatistics
William “Student” Sealy Gosset Professor
Director, Biostatistics Pre-Doctoral NHLBI Training Program
Director, Post-Doctoral NHLBI Training Program in Statistical Genetics
Ryals Public Health Bldg 420D
1665 University Blvd
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 934-4907
Fax: (205) 975-2541
E-mail: htiwari@uab.edu
Full CV

Dr. Tiwari received his Ph.D. in mathematics from the University of Notre Dame, South Bend, Indiana. While being a faculty at the University of Maine, he got interested in statistical genetics, and completed a post-doctoral fellowship in Statistical Genetics under Prof. Robert Elston in the Department of Biometry and Genetics at Louisiana State University Medical center, New Orleans and at the Case Western Reserve University in Cleveland. Subsequently, he worked as a faculty member in the Department of Epidemiology and Biostatistics at Case Western Reserve University. In January 2002, he joined as a faculty in the Department of Biostatistics (Section on Statistical Genetics) at UAB. His research interests include Genetic Linkage Analysis, Disequilibrium Mapping, Population Genetics, Molecular Evolution, Bioinformatics, and Genetics of Infectious Diseases. Currently, he is involved in gene mapping studies of epilepsy, SLE, phonological disorders, and dental traits.

Other News

News from the Center for Alaska Native Health Research
(Volume 4, No.1, Spring 2006)


Click here for listing of recent publications.

  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2006
  • 2005
  • pre 2005
  1. Das M, Irvin MR, Sha J, Aslibekyan S, Hidalgo B, Perry RT, Zhi D, Tiwari HK, Absher D, Ordovas JM, Arnett DK.. Lipid changes due to fenofibrate treatment are not associated with changes in DNA methylation patterns in the GOLDN study. Front Genet. 2015 Sep 29;6:304. [doi: 10.3389/fgene.2015.00304] eCollection 2015. [PMID: 26483836]
  2. Yan Q, Weeks DE, Celedón JC, Tiwari HK, Li B, Wang X, Lin WY, Lou XY, Gao G, Chen W, Liu N. Associating Multivariate Quantitative Phenotypes with Genetic Variants in Family Samples with a Novel Kernel Machine Regression Method. Genetics. 2015 Oct 19. [pii: genetics.115.178590] [Epub ahead of print] [PMID: 26482791]
  3. Singh B, Owens KM, Bajpai P, Desouki MM, Srinivasasainagendra V, Tiwari HK, Singh KK.. Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties. PLoS One. 2015 Oct 15;10(10):e0139846. [doi: 10.1371/journal.pone.0139846] eCollection 2015. [PMID: 26468652]
  4. Akpalu A, Sarfo FS, Ovbiagele B, Akinyemi R, Gebregziabher M, Obiako R, Owolabi L, Sagoe K, Jenkins C, Arulogun O, Adamu S, Appiah LT, Adadey MA, Agyekum F, Quansah JA, Mensah YB, Adeoye AM, Singh A, Tosin AO, Ohifemen O, Sani AA, Tabi-Ajayi E, Phillip IO, Isah SY, Tabari NA, Mande A, Agunloye AM, Ogbole GI, Akinyemi JO, Akpa OM, Laryea R, Melikam SE, Adinku D, Uvere E, Burkett NS, Adekunle GF, Kehinde SI, Azuh PC, Dambatta AH, Ishaq NA, Arnett D, Tiwari HK, Lackland D, Owolabi M. Phenotyping Stroke in Sub-Saharan Africa: Stroke Investigative Research and Education Network (SIREN) Phenomics Protocol. Neuroepidemiology. 2015;45(2):73-82. [doi: 10.1159/000437372] Epub 2015 Aug 19. [PMID: 26304844]
  5. Wojczynski MK, Parnell LD, Pollin TI, Lai CQ, Feitosa MF, O'Connell JR, Frazier-Wood AC, Gibson Q, Aslibekyan S, Ryan KA, Province MA, Tiwari HK, Ordovas JM, Shuldiner AR, Arnett DK, Borecki IB. Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN). Metabolism. 2015 Oct;64(10):1359-71. [doi: 10.1016/j.metabol.2015.07.001] Epub 2015 Jul 3. [PMID: 26256467]
  6. Benza RL, Gomberg-Maitland M, Demarco T, Frost AE, Torbicki A, Langleben D, Pulido T, Correa-Jaque P, Passineau MJ, Wiener HW, Tamari M, Hirota T, Kubo M, Tiwari HK. ET-1 Pathway Polymorphisms Affect Outcome in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2015 Aug 7. [Epub ahead of print] [PMID: 26252367]
  7. Hidalgo B, Aslibekyan S, Wiener HW, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. A family-specific linkage analysis of blood lipid response to fenofibrate in the Genetics of Lipid Lowering Drug and Diet Network. Pharmacogenet Genomics. 2015 Oct;25(10):511-4. [doi: 10.1097/FPC.0000000000000162] [PMID: 26203732]
  8. Aslibekyan S, Demerath EW, Mendelson M, Zhi D, Guan W, Liang L, Sha J, Pankow JS, Liu C, Irvin MR, Fornage M, Hidalgo B, Lin LA, Thibeault KS, Bressler J, Tsai MY, Grove ML, Hopkins PN, Boerwinkle E, Borecki IB, Ordovas JM, Levy D, Tiwari HK, Absher DM, Arnett DK. Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference. Obesity (Silver Spring). 2015 Jul;23(7):1493-501. [doi: 10.1002/oby.21111] [PMID: 26110892]
  9. Akinyemi RO, Ovbiagele B, Akpalu A, Jenkins C, Sagoe K, Owolabi L, Sarfo F, Obiako R, Gebreziabher M, Melikam E, Warth S, Arulogun O, Lackland D, Ogunniyi A, Tiwari H, Kalaria RN, Arnett D, Owolabi MO; SIREN Investigators as Members of the H3Africa Consortium. Stroke genomics in people of African ancestry: charting new paths. Cardiovasc J Afr. 2015 Mar-Apr;26(2 Suppl 1):S39-49. [doi: 10.5830/CVJA-2015-039] [PMID: 25962947]
  10. Owolabi MO, Akarolo-Anthony S, Akinyemi R, Arnett D, Gebregziabher M, Jenkins C, Tiwari H, Arulogun O, Akpalu A, Sarfo FS, Obiako R, Owolabi L, Sagoe K, Melikam S, Adeoye AM, Lackland D, Ovbiagele B; Members of the H3Africa Consortium. The burden of stroke in Africa: a glance at the present and a glimpse into the future. Cardiovasc J Afr. 2015 Mar-Apr;26(2 Suppl 1):S27-38. [doi: 10.5830/CVJA-2015-038] [PMID: 25962945]
  11. Fohner AE, Robinson R, Yracheta J, Dillard DA, Schilling B, Khan B, Hopkins S, Boyer BB, Black J, Wiener H, Tiwari HK, Gordon A, Nickerson D, Tsai JM, Farin FM, Thornton TA, Rettie AE, Thummel KE. Variation in genes controlling warfarin disposition and response in American Indian and Alaska Native people: CYP2C9, VKORC1, CYP4F2, CYP4F11, GGCX. Pharmacogenet Genomics. 2015 Jul;25(7):343-53.[doi: 10.1097/FPC.0000000000000143] [PMID: 25946405]
  12. Tran NT, Aslibekyan S, Tiwari HK, Zhi D, Sung YJ, Hunt SC, Rao DC, Broeckel U, Judd SE, Muntner P, Kent ST, Arnett DK, Irvin MR. PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies. Front Genet. 2015 Apr 8;6:136. [doi: 10.3389/fgene.2015.00136] eCollection 2015. [PMID: 25904937]
  13. Lebrón-Aldea D, Dhurandhar EJ, Pérez-Rodríguez P, Klimentidis YC, Tiwari HK, Vazquez AI. Integrated genomic and BMI analysis for type 2 diabetes risk assessment. Integrated genomic and BMI analysis for type 2 diabetes risk assessment. Front Genet. 2015 Mar 17;6:75. [doi: 10.3389/fgene.2015.00075] eCollection 2015. [PMID: 25852736]
  14. Yan Q, Tiwari HK, Yi N, Gao G, Zhang K, Lin WY, Lou XY, Cui X, Liu N. A Sequence Kernel Association Test for Dichotomous Traits in Family Samples under a Generalized Linear Mixed Model. Hum Hered. 2015;79(2):60-8. [doi: 10.1159/000375409] Epub 2015 Mar 10. [PMID: 25791389]
  15. Vaughan LK, Wiener HW, Aslibekyan S, Allison DB, Havel PJ, Stanhope KL, O'Brien DM, Hopkins SE, Lemas DJ, Boyer BB, Tiwari HK. Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup'ik) population. Metabolism. 2015 Jun;64(6):689-97. [doi: 10.1016/j.metabol.2015.02.008] Epub 2015 Mar 5. [PMID: 25772781]
  1. Irvin MR, Zhi D, Joehanes R, Mendelson M, Aslibekyan S, Claas SA, Thibeault KS, Patel N, Day K, Waite Jones L, Liang L, Chen BH, Yao C, Tiwari HK, Ordovas JM, Levy D, Absher D, Arnett DK. Circulation. Epigenome-Wide Association Study of Fasting Blood Lipids in the Genetics of Lipid Lowering Drugs and Diet Network Study. Circulation. 2014 Aug 12;130(7):565-72. [doi: 10.1161/CIRCULATIONAHA.114.009158] Epub 2014 Jun 11. [PMID: 24920721]
  2. Irvin MR, Zhi D, Aslibekyan S, Claas SA, Absher DM, Ordovas JM, Tiwari HK, Watkins S, Arnett DK. Genomics of Post-Prandial Lipidomic Phenotypes in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study. PLoS One. 2014 Jun 6;9(6):e99509. [doi: 10.1371/journal.pone.0099509] eCollection 2014. [PMID: 24905834]
  3. Yan Q, Tiwari HK, Yi N, Lin WY, Gao G, Lou XY, Cui X, Liu N. Kernel-Machine Testing Coupled with a Rank-Truncation Method for Genetic Pathway Analysis. Genet Epidemiol. 2014 May 21. [doi: 10.1002/gepi.21813] [PMID: 24849109]
  4. Hill AE, Plyler ZE, Tiwari H, Patki A, Tully JP, McAtee CW, Moseley LA, Sorscher EJ. Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNA. PLoS One. 2014 Oct 28;9(10):e109186. [doi: 10.1371/journal.pone.0109186] eCollection 2014. [PMID: 25350658]
  5. Do AN, Irvin MR, Lynch AI, Claas SA, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Tiwari HK, Limdi NA, Arnett DK. The effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study. Front Pharmacol. 2014 Sep 16;5:210. [doi: 10.3389/fphar.2014.00210] eCollection 2014. [PMID: 25278896]
  6. Frazier-Wood AC, Wojczynski MK, Borecki IB, Hopkins PN, Lai CQ, Ordovas JM, Straka RJ, Tsai MY, Tiwari HK, Arnett DK.Genetic risk scores associated with baseline lipoprotein subfraction concentrations do not associate with their responses to fenofibrate. Biology (Basel). 2014 Aug 25;3(3):536-50. [doi: 10.3390/biology3030536] [PMID: 25157911]
  7. Frazier-Wood AC, Aslibekyan S, Absher DM, Hopkins PN, Sha J, Tsai MY, Tiwari HK, Waite LL, Zhi D, Arnett DK. Methylation at CPT1A locus is associated with lipoprotein subfraction profiles. J Lipid Res. 2014 Apr 7;55(7):1324-1330. [PMID: 24711635]
  8. Aslibekyan S, Wiener HW, Havel PJ, Stanhope KL, O'Brien DM, Hopkins SE, Absher DM, Tiwari HK, Boyer BB. DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. J Nutr. 2014 Apr;144(4):425-30. [doi: 10.3945/jn.113.187203] Epub 2014 Jan 29. [PMID: 24477300]
  9. Hidalgo B, Irvin MR, Sha J, Zhi D, Aslibekyan S, Absher D, Tiwari HK, Kabagambe EK, Ordovas JM, Arnett DK. Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study. Diabetes. 2014 Feb;63(2):801-7. [doi: 10.2337/db13-1100] Epub 2013 Oct 29. [PMID: 24170695]
  10. Klimentidis YC, Lemas DJ, Wiener HH, O'Brien DM, Havel PJ, Stanhope KL, Hopkins SE, Tiwari HK, Boyer BB. CDKAL1 and HHEX are associated with type 2 diabetes-related traits among Yup'ik people. J Diabetes. 2014 May;6(3):251-9. [doi: 10.1111/1753-0407.12093] Epub 2013 Oct 29. [PMID: 24112421]
  11. Li P, Tiwari HK, Lin WY, Allison DB, Chung WK, Leibel RL, Yi N, Liu N. Genetic association analysis of 30 genes related to obesity in a European American population. Int J Obes (Lond). 2014 May;38(5):724-9. [doi: 10.1038/ijo.2013.140] Epub 2013 Jul 31. [PMID: 23900445]
  1. Lemas DJ, Klimentidis YC, Wiener HH, O'Brien DM, Hopkins SE, Allison DB, Fernandez JR, Tiwari HK, Boyer BB. Obesity polymorphisms identified in genome-wide association studies interact with n-3 polyunsaturated fatty acid intake and modify the genetic association with adiposity phenotypes in Yup'ik people. Genes Nutr. 2013 Mar 23. [Epub ahead of print] [PMID: 23526194]
  2. Lin WY, Yi N, Lou XY, Zhi D, Zhang K, Gao G, Tiwari HK, Liu N. Haplotype kernel association test as a powerful method to identify chromosomal regions harboring uncommon causal variants. Genet Epidemiol. 2013 Sep;37(6):560-70. [doi: 10.1002/gepi.21740] Epub 2013 Jun 5. [PMID: 23740760]
  3. Kennedy RE, Adragni KP, Tiwari HK, Voeks JH, Brott TG, Howard G. Risk-stratified imputation in survival analysis. Clin Trials. 2013;10(4):530-9. [doi: 10.1177/1740774513493150] Epub 2013 Jul 1. [PMID: 23818434]
  4. Li P, Tiwari HK, Lin WY, Allison DB, Chung WK, Leibel RL, Yi N, Liu N. Genetic association analysis of 30 genes related to obesity in a European American population. Int J Obes (Lond). 2013 Jul 31. [doi: 10.1038/ijo.2013.140] [Epub ahead of print] [PMID: 23900445]
  5. Aslibekyan S, Vaughan LK, Wiener HW, Lemas DJ, Klimentidis YC, Havel PJ, Stanhope KL, O'brien DM, Hopkins SE, Boyer BB, Tiwari HK. Evidence for novel genetic loci associated with metabolic traits in Yup'ik people. Am J Hum Biol. 2013 Aug 1. [doi: 10.1002/ajhb.22429] [Epub ahead of print] [PMCID: PMC3785243]
  6. Danila MI, Reynolds RJ, Tiwari HK, Bridges SL Jr. Ethnic-specific genetic analyses in rheumatoid arthritis: Incremental gains but valuable contributions to the big picture. Arthritis Rheum. 2013 Aug 5. [doi: 10.1002/art.38111]. [Epub ahead of print] No abstract available. [PMID: 23918636]
  7. Klimentidis YC, Lemas DJ, Wiener HH, O'Brien DM, Havel PJ, Stanhope KL, Hopkins SE, Tiwari HK, Boyer BB. CDKAL1 and HHEX are associated with type-2 diabetes-related traits among Yup'ik people. J Diabetes. 2013 Sep 24. [doi: 10.1111/1753-0407.12093] [Epub ahead of print] [PMID: 24112421] [NIHMSAID: NIHMS530630]
  8. Hidalgo B, Irvin MR, Sha J, Zhi D, Aslibekyan S, Absher D, Tiwari HK, Kabagambe EK, Ordovas JM, Arnett DK. Epigenome-wide Association Study of Fasting Measures of Glucose, Insulin, and HOMA-IR in GOLDN. Diabetes. 2013 Oct 29. [Epub ahead of print]. [PMID: 24170695]
  1. Aslibekyan A, Kabagambe EK, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, MD, Hopkins PN, Shen J, Lai C-Q, Ordovas JM, Arnett DK. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network Pharmacogenet Genomics. 2012 Mar; 22(3):191-7. [PMID: 22228203] [PMCID: PMC3275691]
  2. Azuero A, Redden DT, Tiwari HK, Asmellash SG, Piyathilake CJ. A Simple Distribution-Free Algorithm for Generating Simulated High-Dimensional Correlated Data with an Autoregressive Structure, Commun Stat Simul Comput. 2012 Jan 1;41(1):89-98. [PMCID: PMC3217303]
  3. Forsberg LA, Rasi C, Razzaghian HR, Pakalapati G, Waite L, Thilbeault KS, Anna Ronowicz A, Wineinger NE, Tiwari HK, Boomsma D, Westerman MP, Harris JR, Lyle R, Essand M, Eriksson F, Assimes TL, Iribarren C, Strachan E, O'Hanlon TP, Rider LG, Miller FW, Giedraitis V, Lannfelt L, Ingelsson M, Piotrowski A, Pedersen NL, Absher DA, Dumanski JP. Age-related somatic structural changes in the nuclear genome of human blood cells. Am J Hum Genet. 2012 Feb 1. [Epub ahead of print]. [PMID: 22305530]
  4. Lemas DJ, Wiener HW, O'Brien DM, Hopkins S, Stanhope KL, Havel PJ, Allison DB, Tiwari HK. Boyer BB. Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in obesity-related traits in Yup'ik Eskimos. J Lipid Res. 2012 Jan;53(1):175-84. [PMCID: PMC3243474]
  5. Kennedy RE, Howard G, Go RC, Rothwell PM, Tiwari HK, Feng R, McClure LA, Prineas RJ, Banerjee A, Arnett DK. Association between family risk of stroke and myocardial infarction with prevalent risk factors and coexisting diseases.. Stroke. 2012, Apr;43(4):974-9. Feb 9. [doi: 10.1161/STROKEAHA.111.645044] [PMID: 22328552]
  6. You Z, Williams OD, Aban I, Kabagambe EK, Tiwari HK, Cutter G. Response to the Letter 'Efficiency loss due to varying cluster sizes in cluster randomized trials and how to compensate for it: comment on You et al. (2011)' by van Breukelen and Candel. Clin Trials. 2012;9(1):126-7. No abstract available. [DOI: 10.1177/1740774511429832]
  7. Irvin MR, Zhang Q, Kabagambe EK, Perry RT, Straka RJ, Tiwari HK, Borecki IB, Shimmin LC, Stuart C, Zhong Y, Hixson JE, Arnett DK. Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network Study. Pharmacogenet Genomics. 2012 May;22(5):367-72. [Epub ahead of print] [PMID: 22336959]
  8. Frazier-Wood AC, Kabagambe EK, Borecki IB, Tiwari HK, Ordovas JM, Arnett DK. Preliminary Evidence for an Association between LRP-1 Genotype and Body Mass Index in Humans. PLoS One. 2012;7(2):e30732. Epub 2012 Feb 8. [PMCID: PMC3275600]
  9. Lin W-Y, Tiwari HK, Gao G, Zhang K, Arcaroli JJ, Abraham E, Liu N. Similarity-based multimarker association tests for continuous traits.. Ann Hum Genet. 2012 May;76(3):246-60. [PMCID: PMC3329946] [Available on 2013/5/1].
  10. Wineinger NE, Tiwari HK. The impact of errors in copy number variation detection algorithms on association results. PLoS One. 2012;7(4):e32396. Epub 2012 Apr 16. [PMCID: PMC3327691]
  11. Frazier-Wood AC, Ordovas JM, Straka RJ, Hixson JE, Borecki IB, Tiwari HK, Arnett DK. The PPAR Alpha gene is associated with triglyceride, low-density cholesterol, and inflammation marker response to fenofibrate intervention: The GOLDN Study. Pharmacogenomics J. 2012 May 1. [doi: 10.1038/tpj.2012.9] [Epub ahead of print]. [PMID: 22547144]
  12. Sung YJ, Gu CC, Tiwari HK, Arnett DK, Broeckel U, Rao DC. Genotype Imputation for African Americans using data from HapMap Phase II versus 1000 Genomes Project. Genet Epidemiol. 2012 May 29. [doi: 10.1002/gepi.21647]. [Epub ahead of print]
  13. Zhi D, Irvin MR, Gu CC, Stoddard AJ, Lorier R, Matter A, Rao DC, Srinivasasainagendra V, Tiwari HK, Turner A, Broeckel U, Arnett DK. Whole-Exome Sequencing and an iPSC-Derived Cardiomyocyte Model Identifies Four Novel Genes for Left Ventricular Hypertrophy in Blacks. Front Genet. 2012;3:92. Epub 2012 May 28. [PMID: 22654895] [PMCID: PMC3361011]
  14. Zhao W, Wineinger NE, Tiwari HK, Moseley TM, Broeckel U, Arnett DK, Kardia SLR, Kabagambe E, Sun YV. Three common copy number variants associated with obesity related traits in African Americans: a joint analysis between GENOA and HyperGEN. Obesity (Silver Spring). 2012 Jun 22. [doi: 10.1038/oby.2012.162] [Epub ahead of print] [PMID: 22836685]
  15. Lin WY, Yi N, Zhi D, Zhang K, Gao G, Tiwari HK, Liu N. Haplotype-Based Methods for Detecting Uncommon Causal Variants With Common SNPs. Genet Epidemiol. 2012 Jun 15. [doi: 10.1002/gepi.21650] [Epub ahead of print]. [PMID: 22706849]
  16. Frazier-Wood AC, Aslibekyan S, Borecki IB, Hopkins PN, Lai CQ, Ordovas JM, Straka RJ, Tiwari HK, Arnett DK. Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate. Pharmacogenet Genomics. 2012 Oct;22(10):750-757. [PMID: 22890011]
  17. Aslibekyan S, Goodazari MO, Frazier-Wood AC, Yan X, Irvin MR, Tiwari HK, Guo X, Straka RJ, Taylor KD, Tsai MY, Hopkins PN, Korenman SG, Borecki IB, Chen YI, Ordovas JM, Rotter JI, Arnett DK. Variants identified in a GWAS Meta-Analysis is for Blood Lipids Are Associated with the lipid response fenofibrate. PLoS One. 2012;7(10):e48663. [doi: 10.1371/journal.pone.0048663] Epub 2012 Oct 31. [PMCID: PMC3485381]
  18. Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. Nutr Metab Cardiovasc Dis. 2013 Oct;23(10):987-94. [doi: 10.1016/j.numecd.2012.07.010] [PMID: 23149075] [PMCID: PMC3578131]
  19. Frazier-Wood AC, Manichaikul A, Aslibekyan S, Borecki IB, Goff DC, Hopkins PN, Lai CQ, Ordovas JM, Post WS, Rich SS, Sale MM, Siscovick D, Straka RJ, Tiwari HK, Tsai MY, Rotter JI, Arnett DK. Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity. Hum Genet. 2012 Dec 22. [Epub ahead of print] [PMID: 23263444]
  20. Makowsky R, Yan Q, Wiener HW, Sandel M, Aissani B, Tiwari HK, Shrestha S. The utility of mitochondrial and y chromosome phylogenetic data to improve correction for population stratification. Front Genet. 2012;3:301. [doi: 10.3389/fgene.2012.00301] Epub 2012 Dec 21. [PMCID: PMC3527715]
  21. Frazier-Wood AC, Kabagambe EK, Wojczynski MK, Borecki IB, Tiwari HK, Smith CE, Ordovas JM, Arnett DK. The association between LRP-1 variants and chylomicron uptake after a high fat meal. Nutr Metab Cardiovasc Dis. 2013 Feb 26. pii: S0939-4753(13)00002-1. [doi: 10.1016/j.numecd.2012.12.007].
  1. De Luca M, Crocco P, Wiener H, Tiwari HK, Passarino G, Rose G. Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjects. Exp Gerontol. 2011 Jan;46(1):60-4. [PMID: 20951195] [PMCID: PMC2998567]
  2. Wineinger NE, Patki A, Meyers KJ, Broeckel U, Gu CC, Rao D, Devereux RB, Arnett DK, Tiwari HK. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study. BMC Med Genomics. 2011 Jan 11;4(1):4. [PMID: 21223598] [PMCID: PMC3027088]
  3. Arnett DK, Meyers KJ, Devereux RB, Tiwari HK, Gu CC, Vaughan LK, Perry RT, Patki A, Claas SA, Sun YV, Broeckel U, Kardia SL. Genetic Variation in NCAM1 Contributes to Left Ventricular Wall Thickness in Hypertensive Families. Circ Res. 2011 Jan 6. [PMID: 21212386] [NIHMSID: NIHMS269241]
  4. Tiwari HK, Schork NJ (2011). Grand Challenges in Statistical Genetics/Genomics Methodology. Frontiers in Statistical Genetics and Methodology. Front Genet. 2011;2:5. Epub 2011 Feb 24. [PMCID: PMC3268565]
  5. Tiwari HK, Birkner T, Moondan A, Zhang S, Page GP, Patki A, Allison DB (2011). Accurate and Flexible Power: Calculations on the Spot: Applications to Genomic Research. Statistics and Its Interface. Volume 4 (2011) 353-358. [PMCID: PMC3196559]
  6. Howard G, McClure LA,Moy CS, Safford MM, Cushman M, Judd SE, Kissela BM, Kleindorfer DO, Howard VJ, Rhodes DJ, Muntner P, Tiwari HK. Imputation of Incident Events in Longitudinal Cohort Studies. Am J Epidemiol. 2011 Jul 29. [PMCID: PMC3166710]
  7. Wineinger NE, Pajewski NM, Tiwari HK. A method for assessing linkage disequilibrium between CNVs and SNPs inside CNVRs. Front Genet. 2011 Apr 25;2(17). pii: 00017. [PMCID: PMC3109359]
  8. Wineinger NE, Pajewski NM, Kennedy RE, Wojczynski MK, Vaughan LK, Hunt SC, Gu CC, Rao DC, Lorier R, Broeckel U, Arnett DK, Tiwari HK. Characterization of autosomal copy number variation in African Americans: the HyperGEN study. Eur J Hum Genet. 2011 Dec;19(12):1271-5. [PMCID: PMC3230358]
  9. Wood AC, Glasser S, Garvey WT, Kabagambe EK, Borecki IB, Tiwari HK, Sai MY, Hopkins PN, Ordovas JM, Arnett DK. Lipoprotein Lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the Metabolic Syndrome Lipids in Health and Disease 2011 Aug 19;10(1):143. [PMCID: PMC3180704]
  10. Wood AC, Kabagambe EK, Borecki IB, Tiwari HK, Ordovas JM, Arnett DK. Dietary carbohydrate modifies the inverse association between saturated fat intake and cholesterol on very low-density lipoproteins. Lipid Insights 2011:4 7–15. [PMCID: PMC3170517]
  11. Irvin MR, Wineinger N, Rice TK, Pajewski NM, Kabagambe EK, Gu CC, Pankow J, North KE, Wilk JB, Freedman BI, Franceschini N, Broeckel U, Tiwari HK, Arnett DK. Genome-Wide Detection of Allele Specific Copy Number Variation Associated with Insulin Resistance in African Americans from the HyperGEN Study. PLoS One. 2011;6(8):e24052. Epub 2011 Aug 25. [PMCID: PMC3162025]
  12. Tiwari HK, Patki A, Lieberman J, Stroup TS, Allison DB, Leibel RL, Chung WK. Association of allelic variation in genes mediating aspects of energy homeostasis with weight gain during administration of antipsychotic drugs (CATIE Study). Front Genet. 2011 Sep 1; 2(56). pii: 00056. [PMCID: PMC3202977]
  13. Irvin MR, Shrestha S, Chen YI, Wiener HW, Haritunians T, Vaughan LK, Tiwari HK, Taylor KD, Scherzer R, Grunfeld C, Rotter JI, Arnett DK. Genes Linked to Energy Metabolism and Immunoregulatory Mechanisms are Associated with Subcutaneous Adipose Tissue Distribution in HIV-infected Men. Pharmacogenet Genomics. 2011 Sep 3. [PMCID: PMC3210910]
  14. Frazier-Wood AC, Glasser S, Garvey WT, Kabagambe EK, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. A clustering analysis of lipoprotein diameters in the metabolic syndrome. Lipids Health Dis. 2011 Dec 19;10:237. [PMCID: PMC3260106]
  1. Tiwari HK, Patki A, Allison DB. Within-Cluster Resampling (Multiple Outputation) for Analysis of Family Data: Ready for Prime-Time? Statistics and Its Interface. Volume 3 (2010) 169–175.
  2. Irvin MR, Kabagambe EK, Tiwari HK, Parnell L, Straka R, Tsai M, Ordovas J, Arnett DK. Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the GOLDN Study. Circulation: Cardiovascular Genetics. 2010 Oct 1;3(5):462-7. [PMID: 20729559]
  3. Irvin MR, Lynch AI, Kabagambe E, Tiwari HK, Barzilay J, Eckfeldt J, Boerwinkle E, Davis B, Ford C, Arnett DK. Pharmacogenetic Association of Hypertension Candidate Genes with Fasting Glucose in the GenHAT Study. Journal of Hypertension. J Hypertens. 2010 Jun 23. [PMID: 20577119] [Epub ahead of print]
  4. Shrestha S, Aissani B, Tiwari HK, Wiener HW. Association test of multiallelic gene copy numbers in family trios. Genet Epidemiol. 2010 Jan;34(1):2-6. [PMID: 19399904]
  5. Zhang Z, Ersoz E, Lai CQ, Todhunter RJ, Tiwari HK, Gore MA, Bradbury PJ, Yu J, Arnett DK, Ordovas JM, Buckler ES. Mixed linear model approach adapted for genome-wide association studies. Nat Genet. 2010 Apr;42(4):355-60. Epub 2010 Mar 7. [PMID: 20208535]
  6. You Z, Williams OD, Aban I, Kabagambe EK, Tiwari HK, Cutter G. Relative efficiency and sample size for cluster randomized trials with variable cluster sizes. Clin Trials. 2010 Dec 16. [PMID: 21163852]
  1. Chung WK, A, Matsuoka N, Boyer BB, Liu N, Musani SK, Katsanis N, Johnson SB, Gregersen P, Allison DB, Leibel RL, Tiwari HK (2009). Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yu’pik Eskimo populations. Human Heredity, 67(3):193-205. [PMID: 19077438]
  2. Vaughan LK, Divers J, Padilla M, Redden DT, Tiwari HK, Pomp D, Allison DB (2009). The use of plasmodes as a supplement to simulations: A simple example evaluating individual admixture estimation methodologies. Computational Statistics and Data Analysis. 53(5):1755-1766 [doi: 10.1016/j.csda.2008.02.032].
  3. Baye TM, Tiwari HK, Allison DB, Go RC (2009). Database mining for selection of SNP markers useful in admixture mapping. BioData Min. Feb 14;2(1):1. [PMID: 19216798]
  4. Feng R, McClure L, Tiwari HK, Howard G (2009). A new estimate of family disease history providing improved prediction of disease risks. Stat Med. Apr 15;28(8):1269-83. [PubMed: 19170247]
  5. Padilla MA, Divers J, Vaughan LK, Allison DB, Tiwari HK (2009). Multiple Imputation to Correct for Measurement Error in Genetic Structured Association Testing. Hum Hered. Apr 1;68(1): 65-72. [PMID: 19339787]
  6. Gibson AW, Li FJ, Wu J, Edberg JC, Su K, Cafardi J, Wiener H, Tiwari H, Kimberly RP, Davis RS. The FCRL3 -169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+B cells. Arthritis Rheum. 2009 Nov;60(11):3510-2. PMCID: PMC2784265 [PMID: 19877046]
  1. Bruder C, Piotrowski A, Gijsbers A, Andersson R, Erickson S, Diaz de Ståhl T, Menzel U, Sandgren J, von Tell D, Poplawski A, Crowley M, Crasto C, Partridge E, Tiwari HK, Allison D, Komorowski J, van Ommen G-J, Boomsma D, Pedersen N, den Dunnen J, Wirdefeldt K, Dumanski J (2008) Phenotypically concordant and discordant monozygotic twins display different DNA copy number variation profiles..Am J Hum Genet. 2008 Mar;82(3):763-71. [PMID: 18304490]
  2. Tiwari HK, Barnholtz-Sloan J, Wineinger N, Padilla MA, Vaughan LK, Allison DB. Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles. Hum Hered. 2008;66(2):67-86. [PMID: 18382087]
  3. Wojczynski MK, Tiwari HK. Definition of phenotype. Adv Genet. 2008;60:75-105. Review. [PMID: 18358317]
  4. Wineinger N, Kennedy R, Erickson S, Wojcynski M, Bruder C, Tiwari HK (2008) Statistical Issues in the Analysis of DNA Copy Number Variations Data. Int J Computational Biology and Drug Design, Vol 1, No. 4, 368-395. [DOI: 10.1504/IJCBDD.2008.022208]
  1. Musani SK, Shriner D, Liu N, Feng R, Coffey CS, Yi N, Tiwari HK, Allison DB (2007) Detection of gene x gene interactions in genome-wide association studies of human population data. Hum Hered 63(2):67-84. [[PMID: 17283436]
  2. Li J, Cowden LG, King JD, Briles DA, Schroeder HW Jr, Stevens AB, Perry RT, Chen Z, Simmons MS, Wiener HW, Tiwari HK, Harrell LE, Go RC. Effects of chronic stress and interleukin-10 gene polymorphisms on antibody response to tetanus vaccine in family caregivers of patients with Alzheimer's disease. Psychosom Med. 2007 Jul;69(6):551-9. [PMID: 17634568]
  3. Wessel J, Schork AJ, Tiwari HK, Schork NJ (2007). Powerful designs for genetic association studies that consider twins and sibling pairs with discordant genotypes. Genet Epidemiol. 2007 Nov;31(7):789-96. [PMID: 17549743]
  4. Shriner D, Vaughan LK, Padilla MA, Tiwari HK. Problems with genome-wide association studies. Science. 2007 Jun 29;316(5833):1840-2 (letter). [PMID: 17600199]
  5. Matsuoka N, A Patki, Tiwari HK, Luke A, Johnson SB, Gregersen PK, Allison DB, Leibel RL, Chung WK (2007). Association of MC3R with Body Mass Index in African-Americans. International Journal of Body Composition. Vol 5, No 4: 123-129.
  1. Matsuoka N, Patki A, Tiwari HK, Allison DB, Johnson SB, Gregersen PK, Leibel RL, Chung WK. Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults. Int J Obes (Lond). 2006 Feb;30(2):233-7. [PMID: 16231022]
  2. Hughes LB, Beasley TM, Patel H, Tiwari HK, Morgan SL, Baggott JE, Saag KG, McNicholl J, Moreland LW, Alarcon GS, Bridges Jr SL. Racial/Ethnic Differences in Allele Frequencies of Single Nucleotide Polymorphisms in the Methylenetetrahydrofolate Reductase Gene and Their Influence on Response to Methotrexate in Rheumatoid Arthritis. Ann Rheum Dis. 2006. [PMID: 16439441]
  3. Redden DT, Divers J, Vaughan LK, Tiwari HK, Beasley TM, Fernandez JR, Kimberly RP, Feng R, Padilla MA, Liu N, Miller MB, Allison DB. Regional Admixture Mapping and Structured Association Testing: Conceptual Unification and an Extensible General Linear Model. PLoS Genet. 2006 Aug 25;2(8). [PMID: 16934005]
  4. Tiwari HK, Patki A, Padilla M, Beasley TM, Allison DB (2006). Within-cluster Resampling Methods in Association Analysis with Pedigree Data ASA Section on Biometrics Section. The 2006 JSM Proceedings.
  1. Tiwari HK, Holt J, George V, Beasley TM, Amos CI, Allison DB (2005): New Joint Covariance- and Marginal-based Tests for Association & Linkage for Quantitative Traits for random and non-random sampling. Genet Epidemiol 28(1): 48-57. [PMID: 15558568]
  2. Puranam RS, Jain S, Kleindienst AM, Saxena S, Kim MK, Changizi BK, Padma MV, Andrews I, Elston RC, Tiwari HK, McNamara JO (2005): A locus for generalized tonic-clonic seizure susceptibility maps to chromosome 10q25-q26. Ann of Neurol 58:449-458. [PMID: 16130088]
  3. Tiwari HK, Bouchard L, Pérusse L, Allison DB (2005): Is GAD2 gene on chromosome 10p12 a potential candidate gene for human morbid obesity? Nutrition Reviews 63:315-319. [PMID: 16220643]
  4. Tiwari HK, Patki A, Musani S, Beasley TM, George V, Allison DB (2005). Incorporating Missing Data Methods in Familial Genetic Data Analyses. ASA Section on Biometrics Section. The 2005 JSM Proceedings: 402-406.
  5. Howard W. Wiener, Rodney C.P. Go, Hemant Tiwari, Varghese George, Grier Page: COGA Phenotypes and Linkages on Chromosome 2. BMC Genetics 2005, 6(Suppl 1):S125. [PMID: 16451583]
  1. Mohanty SP, Tiwari HK (1979): Powers of Sums of Digits. Mathematics Magazine 52:310-312.
  2. Tiwari HK (1989): On the Reflection Representations of the Hecke Algebras of Certain Weyl Groups. Journal of Algebra 120: 224 - 245.
  3. Knight A, Batzer MA, Stoneking M, Tiwari HK, Scheer WD, Herrera RJ, Deininger PL (1996): DNA Sequences of Alu Elements Indicate a Recent, Single Origin for Modern Humans. Proc Nat Acad Sci USA 93:4360-4364. [PMID: 8633071]
  4. Tiwari HK, Elston RC (1997): Linkage of Multilocus Components of Variance to Polymorphic Markers. Ann Hum Genet 61: 253-261. [PMID: 9250354]
  5. Tiwari HK, Elston RC (1997): Deriving Components of Genetic Variance for Multilocus Models. Genet Epidemiol 14: 1131-1136. [PMID: 9433636]
  6. Tiwari HK, Elston RC (1998):Restrictions on Components of Variance for Epistatic Models. Theor Popul Biol. 54:161-174. [PMID: 9733657]
  7. Tiwari HK, Elston RC (1999): The Approximate Variance of a Function of Random Variables. Biometrical Journal 41: 351-357. [DOI: 10.1002/(SICI)1521-4036(199906)41:3<351::AID-BIMJ351>3.0.CO;2-U ]
  8. George V, Tiwari HK, Zhu X, Elston RC (1999): A Test of Transmission/ Disequilibrium for Quantitative traits in Pedigree Data using Multiple Regression. Am J Hum Genet 65: 236-245. [PMID: 10364537]
  9. Tiwari HK, Zhu X, Elston RC, Shu Y, George V (1999): Association and linkage analysis of ICD-10 diagnosis of alcoholism. Genet Epidemiol 17: S343-347. [PMID: 10597460]
  10. George V, Tiwari HK, Shu Y, Zhu X, Elston RC (1999): Linkage analysis of alcoholism by regression of parental transmission. Genet Epidemiol 17: S157-161. [PMID: 10597429]
  11. Shete S, Tiwari HK, Elston RC (2000): On estimating the heterozygosity and polymorphism information content value. Theor Popul Biol 57:265-271. [PMID: 10828218]
  12. Jedrey CM, Chen C-H, Moser KL, Wedig G, George V, Tiwari HK (2001): Transmission/Disequilibrium test analysis of total serum IgE levels in Hutterite and Collaborative Study on the Genetics of Asthma data sets. Genet Epidemiol 21:298-302. [PMID: 11793686]
  13. Hall MA, Norman P, Thiel B, Tiwari H, Peiffer A, Vaughan RW, Prescott S, Leppert M, Schork NJ, Lanchbury JS (2002): Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12 and 18 control variation in levels of T and B lymphocyte sub-populations. Am. J. Hum. Genet. 70:1172-1182. [PMID: 11951176]
  14. Valiathan M, Tiwari HK, Elston RC, Hans MB (2002): Genetic epidemiology: dental phenotypes in focus. Craniofacial Growth Series. Vol 39: 237-255.
  15. Gass JU, Valiathan M, Tiwari HK, Hans MG, Elston RC (2003): Familial correlations and heritability of maxillary midline diastema. Am J Orthod Dentofacial Orthop 2003;123:29-34. [PMID: 12532061]
  16. Thiel BA, Chakravarti A, Cooper RS, Luke Amy, Lewis S, Lynn A, Tiwari HK, Schork NJ, Weder AB (2003): A genome wide linkage analysis investigating the determinants of blood pressure in Caucasians and African Americans Am J Hypertens. 16: 151-153. [PMID: 12559684]
  17. Fullerton J, Cubin M, Tiwari H, Wang C, Bomhra A, Davidson S, Miller S, Fairburn C, Goodwin G, Neale M, , Fiddy S, Mott R, Allison DB, Flint J (2003): Linkage analysis of extremely discordant and concordant sibling pairs identifies QTL that influence variation in the human personality trait neuroticism. Am J Hum Genet 72(4):879-90. [PMID: 12612864]
  18. Stein CM, Guwatudde D, Nakakeeto M, Peters P, Elston RC, Tiwari HK, Mugerwa R, Whalen C (2003): Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. J Infect Dis 187: 1679-85. [PMID: 12751024]
  19. Wiener H, Elston RC, Tiwari HK (2003): X-linked Extension of the Revised Haseman-Elston Algorithm for Linkage Analysis in Sib Pairs. Hum Hered 55:97-107. [PMID: 12931048]
  20. Stein CM, Song Y, Elston RC, Jun G, Tiwari HK, Iyenger SK (2003): Structural equation model-based genome scan for metabolic syndrome. BMC Genetics 4 (Suppl 1):S99. [PMID: 14975167]
  21. Bridges, Jr. SL, Hughes LB, Mikuls TR, Howard G, Tiwari HK, McNicholl JM, Alarcón GS, and Moreland LW for CLEAR Investigators (2003): Early Rheumatoid Arthritis in African-Americans: The CLEAR Registry. Clin Exp Rheumatol 21(Suppl. 31): S138-S145. [PMID: 14969066]
  22. Tiwari HK, Allison DB (2003): Do allelic variants of SLC6A14 predispose to obesity? J Clin Invest 112 (11):1633-1636. (Editorial) [PMID: 14660737]
  23. Tiwari HK, Allison DB. IMS sponsored mini-conference on Comparative Genomics, IMS Bulletin, Vol 32, Issue 2, page 12, March/April 2003.
  24. Rankinen T, Tiwari HK (2004): Genome scans for Human Nutritional Traits. What have we learned? Nutrition 20(1):9-13. [PMID: 14698008]
  25. Criswell LA, Lum RF, Turner KN, Woehl B, Tiwari HK, Edberg JC, Kimberly RP, Finck BK, Leff J, Whitmore J, Moreland LW, Seldin MF, and Bridges, Jr. SL (2004): The Influence of Genetic Variations in the HLA Class II and TNF-LTA Regions on Response to Treatment of Early Rheumatoid Arthritis with Methotrexate or Etanercept. Arthritis & Rheumatism, September 2004, 50:9; pp. 2750-2756. [PMID: 15457442]
  26. Tiwari HK, Holt J, George V, Beasley TM, Amos CI, Allison DB (2004): Power and cost consideration in joint tests of association & linkage for quantitative traits. ASA Section on Biometrics Section. The 2004 JSM proceedings: 484-488.
  27. George V, Elston RC & Tiwari HK (2004): Two-Stage Designs for Gene-Disease Association Studies. ASA Section on Biometrics Section. The 2004 JSM Proceedings: 338-343.