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Ana Inés Vázquez, Ph.D.

Ana Inés Vázquez Department of Biostatistics
Ryals Public Health Bldg, 327K
University of Alabama at Birmingham
Birmingham, AL 35294
Phone: (205) 975-9148
Fax: (205) 975-2540
E-mail: avazquez@uab.edu
Full CV


I am an Assistant Professor in the Section on Statistical Genetics in the Biostatistics Department at the University of Alabama Birmingham (UAB). I completed postdoctoral work in the Section on Statistical Genetics and Office of Energetics at UAB after graduating with an M.S. and PhD in Quantitative Genetics and a Certificate in Bioinformatics at the University of Wisconsin-Madison. My areas of interest include the development and use of genomic-based statistical methods for human health, the genetic architecture of complex traits, and the investigation of the effects of obesity on risk of disease. Some of my current projects include the examination of shrinkage methods in models where dense molecular markers are used to predict phenotypic outcomes. One such project focuses on marker selection strategies to improve the predictive ability of genetic predisposition to diabetes. I am also involved in research examining the properties and performance of these models in unrelated human populations and have examined the effects of the number of markers in the predictive ability of dense arrays of variants for both human and animal populations, which has allowed us to evaluate which factors affect genomic predictions. My most recent project involves the development of new multivariate analysis approaches of correlated phenotypes, including obesity and other body composition characteristics of humans using genomic data to uncover common genetic roots between these traits. In another current project, I am assessing predictive genomic-based models for the prediction of treatment response, cancer recurrence, and metastasis development in cancer patients, with a greater focus on cutting-edge statistical and computational methodologies.

Publications
 

  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • pre 2009
  1. J.A. Dawson, E.J. Dhurandhar, A.I. Vazquez, D.B. Allison. Propagation of Obesity Across Generations: The Roles of Differential Realized Fertility and Assortative Mating by Body Mass Index. Human Heredity, Ms No.: 201303002. 2013: 75:204-212.
     
  2. G. de los Campos, AI. Vazquez, R. Fernando, Y.C. Klimentidis, and D. Sorensen, 2013. Prediction of Complex Human Traits Using the Genomic Best Linear Unbiased Predictor. Edited by M.E. Goddard. PLoS Genetics 9 (7) 2013: e1003608. [doi:10.1371/journal.pgen.1003608]
     
  3. Y.C. Klimentidis, A.I. Vazquez, G.de los Campos, D.B. Allison, M. Dransfield, V.J. Thannickal, 2013. Heritability of pulmonary function estimated from pedigree and whole-genome markers. Frontiers in Genetics 4: 174.
     
  4. Genome-Enabled Prediction Using the BLR (Bayesian Linear Regression) R-Package. G. de los Campos, P. Perez, A.I. Vazquez and J. Crossa. Chapter Book. In Genome-Wide Association Studies and Genomic Prediction, edited by Cedric Gondro, Julius van der Werf, and Ben Hayes, 299–320. Methods in Molecular Biology 1019. Humana Press. http://link.springer.com/protocol/10.1007/978-1-62703-447-0_12.
     
  5. S. Aslibekyan, H.W. Wiener, G. Wu, D. Zhi, S. Shrestha, G. de los Campos, A.I. Vazquez. Estimating Proportions of Explained Variance: a Comparison of Whole Genome Subsets, In: The Genetic Analysis Workshops 18, 2013. In Press.
     
  6. E.J. Dhurandhar, A. I. Vazquez, G. Argyropoulos, and D.B. Allison. Prediction of Complex Traits With Genetic Information: Even Modest Prediction Accuracy Can Have Substantial Utility. Submitted.
     
  7. Y.C. Klimentidis, A.I. Vazquez, G.de los Campos, Z. Chen, F. Martinez, D.B. Allison. High-dimensional genetic prediction of type-2 diabetes susceptibility. Submitted.
     
  8. A. Shendre, MR Irvin, BE Aouizerat, HW Wiener, AI Vazquez, K Anastos, J Lazar, C Liu, R Karim, NA Limdi, MH Cohen, ET Golub, D Zhi, RC Kaplan, S Shrestha. RYR3 gene variants in subclinical atherosclerosis among HIV-infected women in the Women’s Interagency HIV Study (WIHS). Submitted.
     
  1. A.I. Vazquez, G. de los Campos, Y.C. Klimentidis, G.J.M. Rosa, D. Gianola, N. Yi, and D.B. Allison. A Comprehensive Genetic Approach for Improving Prediction of Skin Cancer Risk in Humans. In Press, Genetics. [doi:10.1534/genetics.112.141705] [PMID: 23051645] Highlight of the issue.
     
  2. A.I. Vazquez, M.A. Perez-Cabal, B. Heringstad, M. Rodrigues-Motta, G.J.M. Rosa, D. Gianola and K.A. Weigel, 2012. Predictive ability of alternative models for genetic analysis of clinical mastitis. Journal of Animal Breeding and Genetics, J. Animal Breeding and Genetics, [doi: 10.1111/j.1439-0388.2011.00950.x]
     
  3. M.A. Pérez-Cabal, A.I. Vazquez, D. Gianola, G.J.M. Rosa and K.A. Weigel, 2012. Accuracy of genome-enabled prediction in a dairy cattle population using different cross-validation layouts. Frontiers in Livestock Genomics, 3 (00027), ISSN:1664-8021. [doi: 10.3389/fgene.2012.00027] [PMID: 22403583] [PMCID: PMC3288819]
     
  4. G. de los Campos, Y.C. Klimentidis, A.I. Vazquez and D.B. Allison. Prediction of expected years of life using whole-genome markers. PLoS ONE, 2012;7(7):e40964. [doi: 10.1371/journal.pone.0040964] [PMID: 22848416] [PMCID: PMC3405107]
     
  5. G de los Campos, AI. Vazquez, D. Sorensen et al. 2012. Prediction of Complex Human Traits Using Genomic BLUP. Poultry Round Table.
  1. R. Makowsky, N.M. Pajewski, Y.C. Klimentidis, A.I. Vazquez, C.W. Duarte, D.B. Allison and G. de los Campos. Beyond missing heritability: Prediction of complex traits,PLoS Genetics, 7(4): e1002051. [doi:10.1371/journal.pgen.1002051]
     
  2. A.I. Vazquez, M.A. Perez-Cabal, B. Heringstad, M. Rodrigues-Motta, G.J.M. Rosa, D. Gianola and K.A. Weigel. Predictive ability of alternative models for genetic analysis of clinical mastitis. Journal of Animal Breeding and Genetics, 2011. [doi: 10.1111/j.1439-0388.2011.00950.x]
     
  3. A.I. Vazquez, G.J.M. Rosa, K.A. Weigel, G. de los Campos, D. Gianola and D.B. Allison. Predictive ability of subsets of SNP with and of parent average for several traits in US Holsteins. J. Dairy Sci., 93: 5942-5949. [DOI:10.3168/jds.2010-3335]
     
  1. A.I. Vazquez, G.J.M. Rosa, K.A. Weigel, G. de los Campos, D. Gianola and D.B. Allison. Predictive ability of subsets of SNP with and of parent average for several traits in US Holsteins. J. Dairy Sci., 93: 5942-5949. [DOI:10.3168/jds.2010-3335]
     
  2. A.I. Vazquez, D.M. Bates, G.J.M. Rosa, D. Gianola and K.A. Weigel. Technical Note: An R package for fitting generalized linear mixed models in animal breeding. J. Anim. Sci., 88: 497-504. 2010. [PMID: 19820058] [DOI:10.2527/jas.2009-1952]
     
  3. K.A. Weigel, G. de los Campos, A.I. Vazquez, G.J.M. Rosa, D. Gianola and C.P. Van Tassell. 2010. Accuracy of direct genomic values derived from imputed single nucleotide polymorphism genotypes in Jersey cattle. J. Dairy Sci., 93: 5423-5435. [DOI:10.3168/jds.2010-3149]
     
  4. A.I. Vazquez, 2010. Statistical Modeling of Genomic Data: Applications to Genetic Markers and Gene Expression. Doctor of Philosophy Dissertation, University of Wisconsin – Madison, 109 pp.
     
  5. A.I. Vazquez, G.J.M. Rosa, K.A. Weigel, D. Gianola, D.B. Allison, 2010. SNP Selection for low-density assays for genomic-enabled predictions using parent averages. Proceedings of the 9th World Congress on Genetics Applied to Livestock Production # 540 and book of abstracts, p 145. August 1-6, Leipzig, Germany.
     
  6. M.A. Pérez-Cabal, A.I. Vazquez, D. Gianola, G.J.M. Rosa, and K.A. Weigel, 2010. Accuracy of genomic predictions in USA Holstein cattle from different training-testing designs. Proceedings of the 9th World Congress on Genetics Applied to Livestock Production # 563 and book of abstracts, p 150. August 1-6, Leipzig, Germany.
     
  7. K.A. Weigel, G. de los Campos, A.I. Vazquez, C.P. Van Tassell, G.J.M. Rosa, D. Gianola, J.R. O'Connell, P.M. VanRaden and G.R. Wiggans, 2010. Genomic selection and its effects on dairy cattle breeding programs. Proceedings of the 9th World Congress on Genetics Applied to Livestock Production # 119 and book of abstracts, p 19. August 1-6, Leipzig, Germany.
     
  8. G. de los Campos, D. Gianola, G.J.M. Rosa, K.A. Weigel, A.I. Vazquez and D.B. Allison, 2010. Semi-parametric marker-enabled prediction of genetic values using Gaussian processes. Proceedings of the 9th World Congress on Genetics Applied to Livestock Production # 520 and book of abstracts, p 131. August 1-6, Leipzig, Germany.
     
  1. A.I. Vazquez, K.A. Weigel, D. Gianola, D.M. Bates, M.A. Perez-Cabal, G.J.M. Rosa, and Y.M. Chang. Poisson versus Threshold Models for Genetic Analysis of Clinical Mastitis in US Holsteins. J.Dairy Sci. 92:5239-5247. 2009. [DOI:10.3168/jds.2009-2085]
     
  2. A.I. Vazquez, D. Gianola, D.M. Bates, K.A. Weigel, and B. Heringstad. Assessment of Poisson, Logit and Linear Models for Genetic Analysis of Clinical Mastitis in Norwegian Red Cows. J. Dairy Sci., 92: 739-748. 2009. [DOI:10.3168/jds.2008-1325]
     
  3. G.J.M Rosa and A.I. Vazquez. Integrating biological information into the statistical analysis and design of microarray experiments. Animal Journal. 2009. [DOI:10.1017/S1751731109991054]
     
  4. G. Quintans, A.I. Vazquez and K.A. Weigel. Effect of suckling restriction with nose plates and premature weaning on postpartum anoestrous interval in primiparous cows under range conditions. Animal Reproduction Science, 116: 10-18. 2009. [DOI:10.1016/j.anireprosci.2008.12.007]
     
  5. M.A. Perez-Cabal, G. de los Campos, A.I. Vazquez, D. Gianola, G.J.M. Rosa, K.A. Weigel and R. Alenda. Genetic Evaluation of Susceptibility to clinical mastitis in Spanish Holstein cows. J. Dairy Sci., 92: 3472-3480.2009. [DOI:10.3168/jds.2008-1978]
  1. A.I. Vazquez. Analysis of number of episodes of clinical mastitis in Norwegian Red and Holstein cows with Poisson and categorical data mixed models. Master of Science Thesis. University of Wisconsin – Madison, 162 pp. 2007.
     
  2. F. Dutra, A.I. Vazquez, G. Banchero and G., Quintans. Perinatal lesions in the central nervous system in twin lambs. In: XXXI Jornadas Uruguayas de Buiatría, pp 133-137. 2003.
     
  3. A.I. Vazquez and P. Lacuesta. Effect of the early weaning and body condition on the reproductive performance of first calf cows. Thesis of Universidad de la República. Montevideo, Uruguay. 2001.

 

Years: 2011 - 2012 (Postdoctoral Fellow)
          2010 - 2011 (Statistician I)
Mentor(s): Nengjun Yi, Ph.D. & David B. Allison, Ph.D.
Current Position: Assistant Professor, Department of Biostatistics, Section on Statistical Genetics, The University of Alabama at Birmingham

In October, 2012 completed her training with us and moved on to a position as Assistant Professor in the UAB Department of Biostatistics. She can be contacted at avazquez@uab.edu.