Healthy individuals display a reduction in blood pressure or “dip” during the nighttime. Loss of the diurnal blood pressure rhythm (rhythm observed from day to night) results in nocturnal hypertension. Salt-sensitive individuals are significantly more likely to have nocturnal hypertension and both phenotypes are common in the US population. High salt diets are prevalent across the US, further advancing salt-sensitivity. Salt-sensitivity and nocturnal hypertension promote exaggerated risk of hypertension and renal disease. There is a void in our understanding of salt-sensitive mechanisms leading to renal dysfunction in concert with the loss of diurnal blood pressure rhythm. The overall goal of this project is to elucidate novel salt-dependent pathways leading to renal dysfunction and nocturnal hypertension with a non-dipping blood pressure phenotype.