In healthy people, blood pressure goes down at night. Studies from Europe and Asia suggest that high blood pressure at nighttime is associated with increased cardiovascular disease risk. In this project we will identify whether African Americans have a higher prevalence of nocturnal hypertension and non-dipping blood pressure, identify whether the association of risk factors including psychosocial factors and sleep disordered breathing with these phenotypes differ by race and determine the association of nocturnal hypertension and non-dipping blood pressure on target organ damage including left ventricular mass, impaired left ventricular function and a higher prevalence of chronic kidney disease. Additionally, we will estimate the US population burden of nocturnal hypertension and non-dipping blood pressure pattern. Finally, we will use simulation modelling to project the cost-effectiveness of screening for and treating nocturnal hypertension and non-dipping blood pressure.
The population project will be supported by these resources:
CARDIA was designed to investigate racial differences in the development of cardiovascular disease and serves as the foundation for the population project.
ActiveBP Columbia University's Ambulatory Blood Pressure Monitoring (ABPM) Service will ensure high quality data for the population project with over 20 years of experience measuring, analyzing, and reporting data on ABPM.
Jackson Heart Study includes 5,301 African Americans and has extensive data on blood pressure phenotypes and cardiovascular disease outcomes.
REGARDS includes 30,239 participants and has longitudinal data on blood pressure, medication use, and cardiovascular and renal outcomes.