Sadeep Shrestha, PhD

Associate Professor
sshrestha@uab.edu
Office: 
Ryals 217L
Biography: 

Dr. Shrestha received his MHS (Infectious disease/Genetic Epidemiology) and PhD (Genetic Epidemiology) from the Bloomberg School of Public Health, Johns Hopkins University and MS (Biotechnology) from Krieger School of Arts and Sciences, Johns Hopkins University. He was a post-doctoral fellow at the Laboratory of Genomic Diversity, NCI-Frederick before joining the School of Public Health faculty in 2005. 
 

Dr. Shrestha is the recipient of the Quetelet Endowed Professorship in Public Health. His background spans the fields of genetics, molecular biology, epidemiology, forensic science, informatics and big data. He also holds an appointment in the Minority Health Research Center, Center for AIDS Research and the Comprehensive Cancer Center, Informatics Institute, Hugh Kaul Precision Medicine Institute at UAB, and Sparkman Center. He is also a faculty of Genetics and Genomic Sciences. He currently serves in the editorial board of Genes and Immunity, BMC Infectious Diseases, Human Immunology, and Kathmandu University Medical Journal and also served as associate editor of American Journal of Epidemiology from 2010-2013. He is the recipient of the 2013 Graduate School Dean’s Award for Excellence in Mentorship.

Dr. Shrestha directs the Epidemiology Seminar Series.

 

Research Interests

Dr. Shrestha's research interests include Epidemiology, Infectogenomics, Vaccinogenomics, Pharmacogenetics, and Immunogenetics of outcomes and sequelae of HIV and HPV, other viral infections and immune-related complications: 

 

HPV related outcomes and cancers

  • Immunogenetics of HPV persistence/clearance - association studies in WIHS, REACH,     HERS, ALTS & HIM cohorts
  • Biomarkers of HPV-related pre-cancer and cancer progression - gene expression, genetic and “omics” association
  • Epidemiology and co-morbidities in HPV-related cancer patients (cervical, head & neck, anal) using hospital-based electronic medical records
  • Screening of HPV and cervical cancer in Nepal

 

Outcomes and complications in HIV-1 patients

  • Acceleration and accentuation of HIV disease progression – genetic associations in MACS, ALIVE, WIHS, MHCS, HERS, FRAM and REACH
  • Atherosclerosis and aging in HIV – Epidemiology and genetic associations
  • Coinfections and co-morbidities related to HIV infection and treatment, especially in the context of host genetics

 

Kawasaki disease 

KD Immunogenetic Consortium in collaborations with Seattle Children's Hospital and affiliated pediatric clinics in northwest US and Children’s of Alabama

  •    Susceptibility to KD (Trio-based family study & Case-control studies)
  •    Differential response to IVIG treatment
  •    Development and progression of coronary aneurysm 

 

Teaching

He is the course master for 

Epi 731 - Genetic Epidemiology

Epi 635 - Genetics in Public Health

Epi 695/795 - Epidemiology Seminar

Epi 703 - Grant Writing

He also co-directs the Basic Research in Infectious and Genetic Epidemiology (BRIDGE) program, with special interest to study public health challenges in infectious disease by mentoring students, post-docs and junior faculty. He had served as the Director of the Doctoral program in the Department of Epidemiology from 2015-2018.

 

Publications in Pubmed

 

Curriculum Vitae: