7TH SHORT COURSE ON NEXT-GENERATION SEQUENCING: TECHNOLOGY AND STATISTICAL METHODS
| Registration: | https://www.soph.uab.edu/ssg/nhgri_r25/seventhshortcourse/application The registration deadline for the course has expired. |
Held On: |
Mon 12/18/17 – Thu 12/21/17 |
Location: |
University of Alabama at Birmingham 1665 University Blvd, RPHB 107 Birmingham, Al 35294 https://www.uab.edu/map/?ryals |
Lodging: |
SpringHill Suites Downtown UAB 2024 4th Avenue South Birmingham, Alabama 35233 205-322-8600 – Office 205-322-9915 – Fax ROOM RATE: 139.86 (tax included) 2 Queen Beds Check in Time: 3:00PM – Check Out Time: 12:00PM Book your group rate for UAB School of Public Health Cancellation: by 6PM day of scheduled arrival GROUP ACCOMMODATIONS INCLUDE:
METERED PARKING: Available along the street in front of the hotel- typically free on the weekends. Doubletree Hotel by Hilton Residence Inn by Marriott |
- Overview
- Faculty
- Contact
Next-generation sequencing technology is impacting almost all aspects of biomedical research. This technology generates an unprecedented wealth of data that demands novel analysis strategies. While IT infrastructure and bioinformatics developments are obviously required to enable sound information extraction, sophisticated statistical methodologies and algorithms are also essential for interpreting the data. We are calling statisticians, genetic epidemiologists, bioinformaticians, and genome biologists, to discuss the statistical challenges and opportunities in next-generation sequencing data analysis. We believe that this course will provide a venue for exchanging of cutting-edge information and ideas, and fostering collaborations among methodologists, analysts, and biomedical investigators.
Schedule of Events: Agenda
Mon 12/18/17| Time | Topic | Speaker | Resource(s) |
| 08:00 - 09:15 AM | Registration | Wanda Skipwith | |
| 09:15 - 09:30 AM | Introductory Remarks | Hemant Tiwari PhD | |
| 09:30 - 10:30 AM | Technical Overview of NGS (Platforms; chemistry; library construction) | Shawn Levy PhD |  |
| 10:30 - 10:45 AM | Discussion | Shawn Levy PhD | |
| 10:45 - 11:00 AM | BREAK | ||
| 11:00 - 12:00 PM | Next Generation Sequencing in Methylation Studies | Devin Absher, PhD | |
| 12:00 - 12:15 PM | Discussion | Devin Absher, PhD | |
| 12:15 - 01:30 PM | LUNCH BREAK (Local Restaurants) | ||
| 01:30 - 02:30 PM | Decoding the Regulatory Genome through Functional Genomics and high-throughput assays | Dan Savic, PhD | |
| 02:30 - 02:45PM | Discussion | Dan Savic, PhD | |
| 02:45 - 03:00PM | BREAK | ||
| 03:00 - 04:00 PM | Introduction to Virtual Machine | Vinodh, MS | |
| 04:00 - 06:00 PM | Software Demonstration & Hands-on Computing (R & Bioinformatics File Formats) | Vinodh, MS | |
Tue 12/19/17
| Time | Topic | Speaker | Resource(s) |
| 09:00 - 10:00 AM | Variant Calling & Assembly NGS Data | David Crossman, PhD | |
| 10:00 - 10:15 AM | Discussion | David Crossman, PhD | |
| 10:15 - 10:30 AM | BREAK | ||
| 10:30 - 11:30 PM | Predicting Causal Variation | Greg Cooper, PhD | |
| 11:30 - 11:45 AM | Discussion | Greg Cooper, PhD | |
| 11:45 - 01:15 PM | LUNCH BREAK (Local Restaurants) | ||
| 01:15 - 02:15 PM | Rare Variants Analysis | Michael Wu, PhD | |
| 02:15 - 02:30 PM | Discussion | Michael Wu, PhD | |
| 02:30 - 02:45 PM | BREAK | ||
| 02:45- 05:00 PM | Software Demonstration & Hands-on Computing (Exome & Whole Genome NGS) | Michael Wu, PhD, David Crossman, PhD | |
Wed 12/20/17
| Time | Topic | Speaker | Resource(s) |
| 09:00 - 10:00 AM | Structural Variant Analysis | Zechen Chong, PhD | |
| 10:00 - 10:15 AM | Discussion | Zechen Chong, PhD | |
| 10:15 - 10:30 AM | BREAK | ||
| 10:30 - 11:30 PM | Transcriptome Analysis | Xiangqin Cui, PhD | |
| 11:30 - 11:45AM | Discussion | Xiangqin Cui, PhD | |
| 11:45 - 01:15 PM | LUNCH BREAK (Local Restaurants) | ||
| 01:15 - 02:15 PM | Methylation using Bisulfite Sequencing | Karen Conneely, PhD | |
| 02:15 - 02:30PM | Discussion | Karen Conneely, PhD | |
| 02:30 - 02:45 PM | BREAK | ||
| 02:45- 06:00 PM | Software Demonstration & Hands-on Computing (RNA-Seq, BSmooth, DSS) | Xiangqin Cui, PhD; Karen Conneely, PhD | |
Thu 12/21/17
| Time | Topic | Speaker | Resource(s) |
| 09:00 - 10:00 AM | ChiP-Seq Data Analysis | Hao Wu, PhD | |
| 10:00 - 10:15 AM | Discussion | Hao Wu, PhD | |
| 10:15 - 10:30 AM | BREAK | ||
| 10:30- 11:30 PM | Single Cell RNA-Seq Analysis | Hao Wu, PhD | |
| 11:30 - 11:45 PM | Discussion | Hao Wu, PhD | |
| 11:45- 01:15 PM | LUNCH BREAK (Local Restaurants) | ||
| 01:15- 03:00 PM | Software Demonstration & Hands-on Computing (ChipSeq) | Hao Wu, PhD | |
| 03:00 PM | Adjourn | ||
UAB Faculty:
External Faculty:
- Dan Savic, PhD – St. Jude Children’s Research Hospital
- Devin Absher, PhD - HudsonAlpha Institute
- Greg Cooper, PhD - HudsonAlpha Institute
- Hao Wu, PhD - Emory Univ.
- Karen Conneely, PhD - Emory Univ.
- Michael Wu, PhD - Fred Hutchinson Cancer Research Center
- Shawn Levy, PhD - HudsonAlpha Institute
- Xiangqin Cui, PhD - Emory Univ.
Full List of Rotating Faculty can be found by Click here.
Contact Information:
Logistics: Wanda C. Skipwith
Department of Biostatistics
1665 University Blvd, RPHB 414
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 975-9193
Email: Statgenetics@uab.edu
Scientific: Hemant K Tiwari, PhD
Department of Biostatistics
1665 University Blvd, 420C
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 934-4907
Email: htiwari@uab.edu
| Sponsors: | National Human Genome Research Institute |
| UAB Department of Biostatistics | |
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NHGRI Disclaimer: This material is based upon work supported by the National Human Genome Research Institute (NHGRI) under Grant No. R25HG006110. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NHGRI.