2nd Short Course on Statistical Genetics and Genomics

Details and Registration Information:  MS Word    PDF


When: Mon 7/9/2012 - Fri 7/13/2012
Location: University of Alabama at Birmingham
1670 University Blvd., Volker Hall Lecture Room B
Birmingham AL 35294-0019
Lodging Options: Doubletree Hotel Birmingham
808 South 20th Street
Birmingham, AL 35205
(205) 933-9000
*mention that you are coming at the request of UAB for our short course for the rate ($119/night; gov't rate not offered)
View more information.


  • Overview & Agenda
  • Bursary Services
  • Faculty & Board
  • Contact

Major efforts are under way to uncover the specific genetic components of many complex human disorders and quantitative traits. These efforts are generating an unprecedented wealth of data that requires sophisticated statistical analysis in order to maximize the information gleaned from each study. Likewise, many advances have been made in statistical methods for the study of complex genetic traits, and new statistical methods continue to be promulgated. To expedite and significantly advance the search for specific genes that predispose to these complex traits, we propose a series of annual hands-on short courses on statistical genetics and statistical genomics which will enable a far greater number of researchers, including clinical researchers, to participate in, contribute to, and lead such research. These short courses will help equip students, post-doctoral fellows, junior investigators and senior investigators new to the field with the statistical genetic approaches necessary to expedite genomic discovery. The courses will be taught by leading experts in statistical genetics/genomics. Each 5-day course will provide substantial "hands-on" computer training that will effectively increase the number and the expertise of investigators who are pursuing genetic and genomic research. We expect approximately 50 students to attend each course, allowing for intensive interaction between students and faculty. Lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. Finally, we will also initiate a new bursary service, providing funding for 10 course participants to travel to visit a course faculty member of their choice to help initiate or finish a particular project. This will provide an unprecedented collaborative opportunity for course participants and faculty.

Schedule of Events: Agenda

**NOTE: You will need Microsoft Silverlight to view videos.

Mon 7/9/12
Time Speaker Topic Resource(s)
08:00 - 08:30 Derry Crawford Registration  
08:30 - 08:45 Hemant Tiwari PhD Introductory Remarks  
08:45 - 09:45 Gregory Pence PhD Ethical Issues in Medical Research in Human Genetics Video
09:45 - 10:00   BREAK
10:00 - 11:00 Gregory Pence PhD Part II - Ethical Issues in Research in Genetics Video
11:00 - 11:15   BREAK
11:15 - 12:15 Nancy Cox PhD Introduction to Genetics & Genomics Video
12:15 - 01:30   LUNCH
01:30 - 03:00 Warren Ewens PhD Introduction to Biostatistics Video
03:00 - 03:15   BREAK
03:15 - 04:15 Jelai Wang Introduction to ssglabvm, a virtual software lab  
04:15 - 06:15 Xiangqin Cui PhD Introduction to R & Bio-conductor  


Tue 7/10/12
Time Speaker Topic Resource(s)
08:00 - 09:15 Carl Langefeld PhD Design, Analysis, and interpretation of GWAS Video
09:15 - 09:30   BREAK
09:30 - 10:45 Suzanne Leal PhD Rare Variants & Exome Sequencing Video
10:45 - 11:00   BREAK
11:00 - 12:15 Mahlet Tadesse PhD Structural Variation & Human Diseases (CNV Analysis) Video
12:15 - 01:30   LUNCH
01:30 - 02:00 Faculty Open Discussion
02:00 - 02:15   BREAK
02:15 - 06:00 Wang, Tadesse and Zhi PLINK, PENNCNV, Exome Sequence data analysis  


Wed 7/11/12
Time Speaker Topic Resource(s)
08:00 - 09:15 Guilherme Rosa PhD Microarrays and RNAseq: technologies and data processing Video
09:15 - 09:30   BREAK
09:30 - 10:45 Guilherme Rosa PhD Design and analysis of gene expression experiments Video
10:45 - 11:00   BREAK
11:00 - 12:15 Shili Lin PhD Epigenomics methods I Video
12:15 - 01:30   LUNCH  
01:30 - 02:00 Faculty Open Discussion
02:00 - 02:15   BREAK
02:15 - 06:00 Drs Cui and Lin Affy, RMANOVA, Epigenomic Analysis, Chip Seq Software (DIME)  
07:00 - 09:00 Participants & Faculty Social and Dinner  


Thu 7/12/12
Time Speaker Topic Resource(s)
08:00 - 09:15 Shili Lin PhD Epigenomics methods II Video
09:15 - 09:30   BREAK
09:30 - 10:45 Alison Motsinger-Reif PhD Pharmacogenetics/ Pharmacogenomics Video
10:45 - 11:00   BREAK
11:00 - 12:15 Gustavo del los Campos PhD Prediction of complex traits using whole genome regressions Video
12:15 - 01:30   LUNCH
01:30 - 02:45 Faculty Open Discussion
02:45 - 03:00   BREAK
03:00 - 06:00 Amit Patki GWAS Imputation  


Fri 7/13/12
Time Speaker Topic Resource(s)
08:00 - 09:15 Laura Kelly Vaughan PhD Pathway & Gene Network approaches for genome-wide association studies Video
09:15 - 09:30   BREAK
09:30 - 10:45 Atul Butte MD, PhD Discovering new drugs & diagnostics from 300 billion points of data Video
10:45 - 12:00 All Faculty Open Discussion
12:00 - 01:30   LUNCH
01:30 - 02:30 Laura Kelly Vaughan PhD Pathways/Gene Network Analysis software  
02:30   Adjourn


Bursary Services. We will offer a novel service to participants to assist them either in their ongoing research projects or in a newly initiated project which could lead to publication in refereed journal or submission of an investigator initiated grant proposal. In addition to attending the regularly scheduled short course itself, one month after the short course participants will be encouraged to submit one page proposals on their projects indicating in each case the specific aim of the project and the name of the rotating faculty with whom they wish to work. Any faculty listed in the rotating faculty list is eligible to provide such service. Advisory board members will serve as reviewers and will assign scores between 1 and 5 to each proposal and convey them to Drs. Tiwari and Allison. We will then select the 10 participants with highest average scores. (In selecting the proposals for Bursary Awards, we also consider diversity in addition, but secondarily, to the scientific quality of the proposal.) We will serve as facilitators, contacting particular faculty to ask whether they are willing to help the participant in initiating and finishing the project. If they agree, we will encourage participants to contact the faculty to arrange to work on the project. When the project is nearly complete, the participant will visit the faculty for two days to get final assistance.

Within one month of the Bursary Service, both participant and faculty will be responsible to provide feedback on their experience and to provide information on the manuscript or grant proposal they submitted together. They may be asked to provide a copy of their manuscript and/or confirmation of the submitted grant proposal (the documents will not be distributed to any one and kept confidential). We will also keep track of publication status as well as approval of the grant proposal by conducting online searches of Pub Med. Medline, and NIH RePORTER to find out whether any of these trainees have publications or funded grants, especially in fields related to genetics. We strongly believe that this will bring high level of collaboration between faculty and participants.

UAB Faculty:

Full List of Rotating Faculty can be found by Click here.

Advisory Board:

  • Robert C Elston, PhD - Statistical Genetics/Genomics, Case Western Reserve University, Cleveland, Ohio
  • Suzanne M Leal, PhD - Linkage/ Association, Department of Molecular and Human Genetics, Baylor University, Houston
  • John K Hewitt, PhD - Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado

Contact Information:

Logistics: Derry Crawford
Phone: (205) 975-9298
Email: statgenetics@ms.soph.uab.edu


Scientific: Hemant K Tiwari, PhD
Department of Biostatistics
1665 University Blvd, 420B
University of Alabama at Birmingham
Birmingham, AL 35294-0022
Phone: (205) 934-4907
Email: htiwari@uab.edu

Materials provided:

  • DNA Microarrays and Related Genomics Techniques: Design, Analysis, and Interpretation of Experiments

Funding Sources:
National Institute of General Medical Sciences (NIGMS)


NIGMS Disclaimer:
This material is based upon work supported by the National Institute of General Medical Sciences (NIGMS) under Grant No. R25GM093044. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NIGMS.