Past Faculty - Christine W. Duarte, Ph.D.

Christine W. Duarte, Ph.D. Department of Biostatistics
Ryals Public Health Bldg
University of Alabama at Birmingham
Birmingham, AL 35294
Full CV
Current Location


Dr. Duarte received her Ph.D. in Bioinformatics with a co-major in Statistics at North Carolina State University in 2009 under the supervision of Dr. Zhao-Bang Zeng. Her dissertation research involved developing a new method for genetic network reconstruction in expression QTL data sets. She has also worked as a Research Scientist for Nature Source Genetics in Ithaca, NY where she was involved in developing optimized experimental designs for QTL experiments as well as developing and applying methods for QTL analysis.

Her current research focuses on developing statistical methods for applying systems biology approaches to high dimensional genomic data analysis. Her work falls into three main areas: 1) Prediction of complex traits and disease from high dimensional genomic data; 2) Developing network models for decomposing genetic effects on complex traits into intermediate phenotypes; and 3) Integrating cross-platform genomic data using network modeling to explain biological processes of interest such as disease etiology and treatment response. Dr. Duarte has ongoing collaborations with several researchers at UAB and other institutions including researchers in the Cancer Center and the Departments of Neurology, Nutrition Sciences, and Immunology.

Publications
 

  • 2011
  • pre 2009
  1. Duarte CW, Zeng ZB. (2011) High Confidence Discovery of Genetic Network Regulators in Expression QTL Data. Genetics 187, 955–964 [PMID: 21212238]
     
  2. Cosgun, E., Limdi, L., and Duarte, C.W. (2011) High Dimensional Pharmacogenetic Prediction of a Continuous Trait using Machine Learning Techniques with Application to Warfarin Dose Prediction in African Americans. Bioinformatics. Accepted
     
  3. Makowsky, R., Pajewski, N.M., Klimentidis, Y.C., Vazquez A.I., Duarte, C.W., Allison, D.B. and de los Campos, G. (2011) Beyond Missing Heritability: Prediction of Complex Traits. PLOS Genetics. Accepted.
     
  1. Coffman CJ, Doerge RW, Simonsen KL, Nichols KM, Duarte CK, Wolfinger RD, McIntyre LM. (2005) Model Selection in Binary Trait Locus Mapping. Genetics 170(3), 1281-97. [PMID: 15834149]
     
  2. Frey, Wolfgang, Woods, Christine K., Chilkoti, Ashutosh (2000) Utraflat Nanosphere Lithography: A New Method to Fabricate Flat Nanostructures. Advanced Materials 12(20), 1515-19. [DOI: 10.1002/1521-4095(200010)12:20<1515::AID-ADMA1515>3.0.CO;2-J]