Past Faculty - Guimin Gao, Ph.D.

Guimin Gao, Ph.D. Department of Biostatistics
Ryals Public Health BldgC
University of Alabama at Birmingham
Birmingham, AL 35294
Full CV
Current Location


Dr. Guimin Gao joined the section of statistical genetics at University of Alabama at Birmingham as a research assistant professor in August 2005. His research focuses on 1) fine mapping of Quantitative Trait Loci (QTL) and complex disease gene in pedigrees, 3) weighted multiple hypothesis testing methods for genome-wide association studies (GWAS), and 3) admixture mapping.

Dr. Gao and his collaborators have proposed computationally efficient haplotyping algorithms and QTL mapping methods for large pedigrees with complex traits, and have developed related computer programs. Recently, Dr. Gao and his postdoctoral fellow have proposed a set of weighted multiple hypothesis testing procedures and applied these procedures to GWAS for artery coronary artery disease and rheumatoid arthritis.

Dr. Gao’s future research interests lie in development and application of statistical and computational method for identifying genetic variants for complex diseases by utilizing genome-wide single-nucleotide polymorphisms, sequencing data and gene expression data. He is also interested in admixture mapping studies in African American populations.

Publications
 

  • 2009
  • 2008
  • 2007
  • pre 2007
  1. Liu Y.J., Ordovas J.M., Gao G., Zhang K., Borecki I., Province, M., Tsai, M., Hixson, J.E., Allison, D.B., Arnett, D. K. (2009) Pharmacogenetic Association of the APOA1/C3/A4/A5 Gene Cluster and Lipid Responses to Fenofibrate - The Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study. Pharmacogenet Genomics. Feb;19(2):161-169 [PMID: 19057464].
     
  2. Kang G., Ye K., Liu L., Allison D.B., Gao G. (2009) Weighted multiple hypothesis testing procedures. Statistical Applications in Genetics and Molecular Biology. Vol. 8 : Iss. 1, Article 23.* *Most Popular Papers (6/12/09-8/7/09) in the journal (* Based on the average number of full-text downloads per day since the paper was posted, http://www.bepress.com/sagmb/topdownloads.html) *The 10 Most Popular Articles in Collection of Biostatistics Research Archive (COBRA) on May 27, 2009. [PMID: 19409067]
     
  3. Gao G., Allison D.B., Hoeschele I. (2009) Haplotyping methods for pedigrees. Hum. Hered. 67:248-266. * *Top 10 articles June 2009 in the journal of Hum Hered. [PMID: 19172084]
     
  4. Kang G., Childers D., Liu L., Zhang K., Gao G. (2009) Application of multiple testing methods for correlated tests to genome-wide association studies. BMC Proceedings. (Accepted)
     
  5. Childers D, Kang G, Liu L, Gao G, Zhang K. (2009) Application of imputation methods for the analysis of genome-wide association studies. BMC Proceedings. (Accepted)
  1. Gao G., Allison D.B., Hoeschele I. (2008) Haplotyping methods for pedigrees. Hum. Hered. (In press).
     
  2. Gao G., Wan W., Zhang S., Redden D., Allison D.B. (2008) Testing for differences in distribution tails to test for differences in ‘maximum’ lifespan. BMC Medical Research Methodology 8:49 (1-10). [PMID: 18655712]
     
  3. Liu Y.J, Ordovas, J.M., Gao G., Zhang K., Borecki I., Province M., Tsai M., Hixson J.E., Allison D.B., Arnett D. K. (2008) The SCARB1 gene is associated with lipid response to dietary and pharmacological interventions. J Hum Genet 53: 709-17. [PMID: 18542840]
     
  4. Gao G., Hoeschele I. (2008) A rapid conditional enumeration haplotyping method in pedigrees. Genet. Sel. Evol. 40:25-36. [PMID: 18096113]
     
  1. Li H., Gao G., Li J., Page G., Zhang K. (2007) Detecting epistatic interactions contributing to human gene expression using the CEPH family data. BMC Proceedings 1 (Suppl 1):S67. [PMID: 18466568]
     
  2. Yoo Y.J., Gao G., Zhang K. (2007) Case-control association analysis of rheumatoid arthritis with candidate genes using related cases. BMC Proceedings 1 (Suppl 1):S33. [PMID: 18466531]
     
  1. Gao G., Hoeschele I. (2005). Approximating identity-by-descent matrices using multiple haplotype configurations on pedigrees. Genetics 171:365-76. [PMID: 15965257]
     
  2. Gao G., Hoeschele I., Sorensen P., Du. F.X. (2004) Conditional probability methods for haplotyping in pedigrees. Genetics 167: 2055-2065. [PMID: 15342540]
     
  3. Deng H.W., Gao G., Li J. L. (2002) Estimation of deleterious genomic mutation parameters in natural populations by accounting for variable mutation effects across loci. Genetics 162: 1487-1500. [PMID: 12454090]
     
  4. Li J. L., Deng H. L., Lai D. B., Xu F. H., Chen J., Gao G. Recker R. R., Deng .H.W. (2001). Toward high-throughput genotyping: dynamic and automatic software for manipulating large-scale genotype data using fluorescently labeled dinucleotide Markers. Genome Research 11, 1304-1314. [PMID: 1143541]
     
  5. Gao G., Fang J. Q. (2001). Stratified capture-recapture methodology in the estimation on the number of cancer incidence cases. Chinese Journal of Epidemiology (Chinese) 22, 223-225. [PMID: 11860884]
     
  6. Gao G., Fang J. Q. (2000). Applications of log-linear Models for Capture-recapture to the estimation of the number of infant death. Journal of mathematical medicine (Chinese) 13, 193-194.