Past Faculty - Xiang-Yang Lou, Ph.D.

Xiang-Yang Lou, Ph.D. Department of Biostatistics
Ryals Public Health Bldg
University of Alabama at Birmingham
Birmingham, AL 35294
Full CV
Current Location

Dr. Lou's research interests include Statistical Genetics, Bioinformatics, Genetic Epidemiology, Biostatistics, and Population Genetics. His research primarily concentrates on developing and applying powerful innovative analysis methods to solve real-world biological problems such as gene-gene and gene-environment interactions, low statistical power, and allelic heterogeneity in genetic data analysis.


  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2006
  • 2005
  • pre 2005
  1. Chen GB, Zhu J, Lou XY (2011). A faster pedigree-based generalized multifactor dimensionality reduction method for detecting gene-gene interactions. Statistics and Its Interface 4 (3): 295-304. [PMID: 21927640] [PMCID: PMC3173778] (the senior author)
  2. Xu HM, Wei CS, Tang YT, Zhu ZH, Sima YF, Lou XY (2011). A new mapping method for quantitative trait loci of silkworm. BMC Genetics 12: 19. [PMID: 21276233] [PMCID: PMC3042969] (the senior author)
  3. Wu JX, Lou XY, Gonda M (2011). Stochastic deletion-insertion algorithm to construct dense linkage maps. Statistics and Its Interface 4 (3): 381-388. [PMID: 21927641] [PMCID: PMC3173768]
  4. Chen GB, Xu Y, Xu HM, Li MD, Zhu J, Lou XY (2011). Practical and theoretical considerations in study design for detecting gene-gene interactions using MDR and GMDR approaches. PLoS One 6 (2): e16981. [PMID: 21386969] [PMCID: PMC3046176] (the senior author)
  5. Wu J, Jenkins JN, McCarty JC, Lou XY (2011). Comparisons of four approximation algorithms for large-scale linkage map construction. Theoretical & Applied Genetics 123 (4): 649-655. [PMID: 21611760] [PMCID: PMC3172867]
  6. Chen GB, Ingram KH, de los Campos G, Yi NJ, Lou XY, Pomp D, Allison DB (2011). A two-step modeling strategy for testing and estimating genetic susceptibility to the Ill-effects of adiposity: Illustration in an outbred F2 mice population. International Journal of Obesity 35: S21-S21.
  7. Lou XY, Allison DB (2011) Statistics in Human Genetics and Molecular Biology by REILLY, C. Biometrics 67: 1672-1673 (Book Reviews)
  8. Li M, Lou XY, Lu Q (2011). On epistasis: a methodological review for detecting gene-gene interactions underlying various types of phenotypic traits. Recent Patents on Biotechnology (accepted).
  1. Chi XF, Lou XY, Shu QY (2010). Combining DNA pooling with selective recombinant genotyping for increased efficiency in fine mapping. Theoretical & Applied Genetics 120 (4): 775-783. [PMID: 19898814] [PMCID: PMC2829194] (the senior author)
  2. Li MD, Xu Q, Lou XY, Payne TJ, Niu T, Ma JZ (2010). Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. American J Medical Genetics B Neuropsychiatric Genetics 153B (3): 745-756. [PMID: 19859904] [PMCID: PMC2924635]
  1. Li MD, Mangold JE, Seneviratne C, Chen GB, Ma JZ, Lou XY, Payne TJ (2009). Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations. PLoS One 4 (9): e7055. [PMID: 19763258] [PMCID: PMC2739294]
  2. Dou BD, Hou BW, Xu HM, Lou XY, Chi XF, Yang JB, Wang F, Ni ZF, Sun QX (2009). Efficient mapping of a female sterile gene in wheat (Triticum aestivum L.). Genetics Research (91 (5): 337-343. [PMID: 19922697]
  3. Chi XF, Lou XY, Yang MCK, Shu QY (2009) An optimal DNA pooling strategy for progressive fine mapping. Genetica 135 (3): 267-281. (the senior author) [PMID: 18506582]
  4. Shi CH, Shi Y, Lou XY, Xu HM, Zheng X, Wu JG (2009) Identification of endosperm and maternal plant QTLs for protein and lysine contents of rice across different environments. Crop and Pasture Science (Australian Journal of Agricultural Research) 60 (3): 295–301. [DOI: 10.1071/CP08234]
  1. Lou XY, Chen GB, Yan L, Ma JZ, Mangold JE, Zhu J, Elston RC, Li MD (2008) A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies. American Journal of Human Genetics 83 (4): 457-467. [PMID: 18834969]
  2. Chen GB, Payne TJ, Lou XY, Ma JZ, Zhu J, Li MD (2008) Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers. Human Genetics 124 (4): 393-398. [PMID: 18777128]
  3. Li MD, Lou XY, Chen GB, Ma JZ, Elston RC (2008) Gene-gene interactions among CHRNA4, CHRNB2, BDNF and NTRK2 in nicotine dependence. Biological Psychiatry 64 (11): 951-957. [PMID: 18534558]
  4. Chi XF, Lou XY, Shu QY (2008) Progressive fine mapping in experimental populations: An improved strategy toward positional cloning. Journal of Theoretical Biology 253 (4): 817-823. (the senior author) [PMID: 18533192]
  5. Li MD, Ma JZ, Payne TJ, Lou XY, Zhang D, Dupont RT, Elston RC (2008) Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample. Molecular Psychiatry 13 (4): 407-416. [PMID: 17579606]
  6. Zheng X, Wu JG, Lou XY, Xu HM, Shi CH (2008) The QTL analysis on maternal and endosperm genome and their environmental interactions for characters of cooking quality in rice (Oryza sativa L.). Theoretical & Applied Genetics 116 (3): 335-342. [PMID: 17989953]
  7. Han LD, Xu HM, Zhu J, Lou XY (2008) Analysis of genetic effects of nuclear-cytoplasmic interaction on quantitative traits: Genetic models for seed traits of plants. Theoretical & Applied Genetics 116 (6): 769–776. [PMID: 18283427]
  8. Zheng X, Wu JG, Lou XY, Xu HM, Shi CH (2008) Mapping and analysis of QTLs on maternal and endosperm genomes for histidine and arginine in Rice (Oryza sativa L.) across environments. Acta Agronomica Sinica 34(3): 369-375. [DOI:10.1016/S1875-2780(08)60016-4]
  1. Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC, Li MD (2007) A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. American Journal of Human Genetics 80 (6): 1125-1137. [PMID: 17503330]
  2. Lou XY, Ma JZ, Sun D, Payne TJ, Li MD (2007) Fine mapping of a linkage region on chromosome 17p13 reveals that associations of GABARAP and DLG4 genes are associated with vulnerability to nicotine dependence in European-Americans. Human Molecular Genetics 16 (2): 142-153. [PMID: 17164261]
  3. Beuten J, Ma JZ, Payne TJ, Lou XY, Dupont RT, Crews KM, Elston RC, Li MD (2007) Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. Biological Psychiatry 61 (1): 48-55. [PMID: 16713586]
  4. Beuten J, Ma JZ, Lou XY, Payne TJ, Li MD (2007) Association analysis of the protein phosphatase regulatory subunit B1 (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. American J Medical Genetics B Neuropsychiatric Genetics 144 (3): 285-290. [PMID: 17171661]
  5. Li MD, Sun D, Lou XY, Beuten J, Payne TJ, Ma JZ (2007) Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. Molecular Psychiatry 12 (5): 462-73. [PMID: 17179996]
  1. Lou XY, Ma JZ, Yang MCK, Zhu J, Liu PY, Deng HW, Elston RC, Li MD (2006) Improvement of mapping accuracy by unifying linkage and association analyses. Genetics 172 (1): 647-661. [PMID: 16172505]
  2. Lou XY, Yang MCK (2006) Estimating effects of a single gene and polygenes on quantitative traits from a diallel design. Genetica 128 (1-3): 471-484. (the senior author) [PMID: 17028974]
  3. Lou XY, Ma JZ, Payne TJ, Beuten J, Crew KM, Li MD (2006) Gene-based analysis suggests associations of the nicotinic acetylcholine receptor β1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) genes with vulnerability to nicotine dependence. Human Genetics 120 (3): 381-389. [PMID: 16874522]
  4. Li MD, Payne TJ, Ma JZ, Lou XY, Zhang D, Dupont RT, Crews KM, Somes G, Williams NJ, Elston RC (2006) A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. American Journal of Human Genetics 79 (4): 745-751. [PMID: 16960812]
  1. Lou XY, Zhu J, Zhang QD, Zang RC, Chen YB, Yu ZL, Zhao YJ (2005) Genetic control of the opaque-2 gene and background polygenes over some kernel traits in maize (Zea mays L.). Genetica 124 (2): 291-300. [PMID: 16134340]
  2. Li MD, Beuten J, Ma JZ, Payne TJ, Lou XY, Garcia V, Duenes AS, Crews KM, Elston RC (2005) Ethnic- and gender-specific association of the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) with nicotine dependence. Human Molecular Genetics 14 (9): 1211–1219. [PMID: 15790597]
  3. Lou XY, Casella G, Todhunter RJ, Yang MCK, Wu R (2005) A general statistical framework for unifying interval and linkage disequilibrium mapping: Towards high-resolution mapping of quantitative traits. Journal of the American Statistical Association 100 (469): 158-171. [DOI: 10.1198/016214504000001295]
  1. Lou XY, Casella G, Littell RC, Yang MCK, Johnson JA, Wu RL (2003) A haplotype-based algorithm for multilocus linkage disequilibrium mapping of quantitative trait loci with epistasis. Genetics 163 (4): 1533-1548. [PMID: 12702696]
  2. Lou XY, Todhunter RJ, Lin M, Lu Q, Liu T, Bliss SP, Casella G, Acland GM, Lust G, Wu RL (2003) The extent and distribution of linkage disequilibrium in Canine. Mammalian Genome 14 (8): 555-564. [PMID: 12925888]
  3. Lin M, Lou XY, Chang M, Wu RL (2003) A general statistical framework for mapping quantitative trait loci in non-model systems: Issue for characterizing linkage phases. Genetics 165 (2): 901-913. [PMID: 14573497]
  4. Wu RL, Ma CX, Lou XY, Casella G. (2003) Molecular dissection of allometry, ontogeny and plasticity: A genomic view of developmental biology. BioScience 53 (11): 1041-1047. [DOI: 10.1641/0006-3568(2003)053[1041:MDOAOA]2.0.CO;2]
  5. Liu PY, Zhu J, Lou XY, Lu Y (2003) A method for marker-assisted selection based on QTLs with epistatic effects. Genetica 119 (1): 75-86. [PMID: 12903749]
  6. Chi XF, Wu DX, Lou XY, Xia YW, Shu QY (2003). Comparative studies on the starch gelatinization characteristics of five cereal crops (in Chinese). Acta Agrocultural Sinica 29 (2): 300-304.
  7. Lou XY, Zhu J (2002) Analysis of genetic effects of major genes and polygenes on quantitative traits. I. Genetic model for diploid plants and animals. Theoretical & Applied Genetics 104 (2-3): 414-421. [PMID: 12582714]
  8. Lou XY, Zhu J (2002) Analysis of genetic effects of major genes and polygenes on quantitative traits. II. Genetic model for seed traits of crops. Theoretical & Applied Genetics 105 (6-7): 964-971. [PMID: 12582922]
  9. Wu RL, Lou XY, Ma CX, Wang XL, Larkins BA, Casella G. (2002) An improved genetic model generates high-resolution mapping of QTL for protein quality in maize endosperm. Proceedings of the National Academy of Sciences of the United States of America 99 (17): 11281–11286. [PMID: 12177407]
  10. Cao LY, Lou XY, Si HM, He LB, Sun ZX (2002) Comparison between two methods of establishing DH population for mapping lox-3 gene in rice (Oryza sativa L.) (in Chinese). Hereditas (BEIJING) 24 (4): 159-162. [PMID: 16118132]
  11. Yu ZL, Zhao JH, Lou XY (1999) Analyses of genetic effects on kernel traits in maize (Zea mays L.) (in Chinese). Zhejiang Agricultural Science 99 (4): 171-174.
  12. Lou XY, Zhu J, Zhang QD, Zang RC, Chen YB (1998) A genetic study on the effects of opaque-2 and polygenes on kernel quality traits in maize. In: Chen LS, Ruan SG, Zhu J (eds), Advanced Topics in Biomathematics: Proceedings of International Conference on Mathematical Biology, Singapore: World Scientific Pub Co pp 143-148.
  13. Lou XY, Zhang QD, Yu ZL, Zhao JH (1998) Studies on genetic effects of some quantitative ear traits in maize (Zea mays L.) (in Chinese). Zhejiang Agricultural Science 98 (1): 21-24.